ID   MAGD4_BOVIN             Reviewed;         740 AA.
AC   A6QLI5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Melanoma-associated antigen D4;
DE   AltName: Full=MAGE-D4 antigen;
GN   Name=MAGED4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc
CC       finger-containing E3 ubiquitin-protein ligases. Proposed to act through
CC       recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at
CC       the E3:substrate complex (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TRIM27. {ECO:0000250}.
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DR   EMBL; BC147977; AAI47978.1; -; mRNA.
DR   RefSeq; NP_001096781.1; NM_001103311.1.
DR   AlphaFoldDB; A6QLI5; -.
DR   SMR; A6QLI5; -.
DR   STRING; 9913.ENSBTAP00000054178; -.
DR   PaxDb; A6QLI5; -.
DR   GeneID; 100125231; -.
DR   KEGG; bta:100125231; -.
DR   CTD; 81557; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   InParanoid; A6QLI5; -.
DR   OrthoDB; 1195799at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1200; -; 1.
DR   Gene3D; 1.10.10.1210; -; 1.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR030091; MAGED4.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736; PTHR11736; 1.
DR   PANTHER; PTHR11736:SF37; PTHR11736:SF37; 1.
DR   Pfam; PF01454; MAGE; 1.
DR   SMART; SM01373; MAGE; 1.
DR   PROSITE; PS50838; MAGE; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Tumor antigen; Ubl conjugation pathway.
FT   CHAIN           1..740
FT                   /note="Melanoma-associated antigen D4"
FT                   /id="PRO_0000346787"
FT   DOMAIN          414..612
FT                   /note="MAGE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..722
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..367
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  81527 MW;  4F9EB1F815F8480A CRC64;
     MAEGSYRKES EGYNVEDMDE GSDEVGEEDM VEGNDYEEFG AFGGYGALTS FDIRILRAFG
     SLGPGFRILA NEPWELENPV LARTLLEAFR MDPETLANET AARAANVARA AASNQAARAA
     ATAARATYNQ VVTNHHPVAT HQASGGDTQP MTSAAQAPAA TPETSVASPH SSRMLVNSEM
     AAPGAPARSP QPQTSSQAQE AAAEGPSTAC AFPQASRASE MDATRPKTAF LGQNDAFDFS
     QPAGVSGMAF PRPKRPAPAQ EAATEGPSVA SRGTQAASAG EGAATRPKTT KSGKALAKTR
     WVEPQNVVAA AAAKAKMATS IPEPESAAAT SQQSAEPWAR MGGKRTKKSK HLDDEYESGE
     EEREPPAVPP TWRASQPLLT TARPQVAPRP SMALRSQVPS RHVLCLPPRN VTLLQERANK
     LVKYLMIKDY KKIPIKRSDM LKDVIREYDE HFPEIIERAT YTLEKKFGIH LKEIDKEEHL
     YILVCTRDSS ARLLGKTKDT PRLSLLLVIL GVIFMNGNRA SEAVLWEALR KMGLRPGVRH
     PFLGDLRKLI TEDFVKQKYL EYKKVPNSSP PEYEFLWGLR ACHETSKMRV LRFIAQYQNR
     DPREWRAHFL EAVDDAFKTM DVDMAEEHAR AQMRAQMNIG EEALIGRWSW DDIQVELLTW
     DEDGDFGDAW SRIPFAFWAR YHQYILNSNR PNRRGTWRAG VSSGTNGAAS ASMLDGPSTS
     STIRTRNAAR TSASFFSWIQ