ID   MAGE1_MACFA             Reviewed;         957 AA.
AC   Q9BE18;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Melanoma-associated antigen E1;
DE   AltName: Full=Alpha-dystrobrevin-associated MAGE Protein;
DE            Short=DAMAGE;
DE   AltName: Full=MAGE-E1 antigen;
GN   Name=MAGEE1; ORFNames=QflA-10248;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc
CC       finger-containing E3 ubiquitin-protein ligases. Proposed to act through
CC       recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at
CC       the E3:substrate complex (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DTNA. Interacts with TRIM28 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=In the
CC       skeletal muscle, found at the postsynaptic membrane and is associated
CC       with a subset of myonuclei. May reside within nuclei and/or in
CC       perinuclear compartments. In peripheral nerves, colocalizes with DTNA
CC       in the Schwann cell membrane (By similarity). {ECO:0000250}.
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DR   EMBL; AB060233; BAB41162.1; -; mRNA.
DR   AlphaFoldDB; Q9BE18; -.
DR   SMR; Q9BE18; -.
DR   STRING; 9541.XP_005594046.1; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
DR   Gene3D; 1.10.10.1200; -; 2.
DR   Gene3D; 1.10.10.1210; -; 2.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736; PTHR11736; 6.
DR   Pfam; PF01454; MAGE; 1.
DR   SMART; SM01373; MAGE; 2.
DR   PROSITE; PS50838; MAGE; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Nucleus; Reference proteome; Repeat;
KW   Tumor antigen; Ubl conjugation pathway.
FT   CHAIN           1..957
FT                   /note="Melanoma-associated antigen E1"
FT                   /id="PRO_0000156730"
FT   DOMAIN          491..690
FT                   /note="MAGE 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   DOMAIN          745..936
FT                   /note="MAGE 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   REGION          1..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          743..957
FT                   /note="Interaction with DTNA"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        46..230
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..245
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..350
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  103349 MW;  0186998C3D967302 CRC64;
     MSLVSQNSRR RRRRVAKATA HNSSWDEMQA PNAPGFPADM PGSDVPQGPS DSQILQGLCA
     SEGPSTSVLP TSAEGPSTFV PPTISEASSA SGQPTVSEGP GTSLLATPSE GLSTSGPPTI
     SKGLCTSVTL AASEGRNTSR PPTSSEEPST SVPATPGEGT STSVPPTASE GPSTSVVPTP
     DEGPSTSVQS TAGEGPSTPV PLTATEGLST SVPDTPDEGL STSVPPTATE GLSTPVPPTP
     DEGPSTSMPA TPGEGRSTTM LPAASDGQSI SLVPTPGKGS STSGPPTATE GLSTSVQPTA
     GEGPSTSVPP TPCGGLSTSV PPTPGEGLST SVPPTATEGL STSVPPTPGE GPSTSVLPTP
     GEGRSTSVPP TASDGSDTSV PPTPGEGPST LVQPTASDRP GSSVLPNPGE GPSTLFSSSA
     SVDRNPSKCS IVLPSPRVTK ASVDSDSEGP KGAEGPIEFE VLRDCESPNS ITIMGLSTPR
     VAITLKPQDP MEQNVAELLQ FLLVKDQSKY PIRESEMREY IVKEYRNQFP EILRRAAAHL
     ECIFRFELRE LDPEARTYIL LNKLGPVPFE GLEESPNGPK MGLLMMILGQ IFLNGNQAKE
     AEICEMLWRM GVQRERRLSI FGNPKRLLSV EFVWQRYLDY RPVTDCKPVE YEFFWGPRSH
     LETTKMKILK FMAKIYNKDP MDWPEQYNEA LEEDAARAFA EGWQALPHFR RPFFEEAAAE
     VASPDSEVSS YSSKYAPHSW PESRLESKAR KLVQLFLLMD STKLPIPKEG ILYYIGRECS
     KVFPDLLNRA ARTLNHVYGT ELVVLDPRNH SYTLYNRREM EETEEIVDSP NRPGNNFLMQ
     VLSFIFIMGN HARESAVWAF LRGLGVQSGR KHVITCRYLS QRYIDSLRVP DSDPVQYEFV
     WGPRARLETS KMKALRYVAR IHRKEPQDWP QQYREAMEDE ANRADVGHRQ FFVHNFR