MAGE1_MOUSE
ID MAGE1_MOUSE Reviewed; 918 AA.
AC Q6PCZ4; Q8BG82; Q8BQ37; Q99PB2;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Melanoma-associated antigen E1;
DE AltName: Full=Alpha-dystrobrevin-associated MAGE Protein;
DE Short=DAMAGE;
DE AltName: Full=MAGE-E1 antigen;
GN Name=Magee1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP INTERACTION WITH DTNA.
RX PubMed=14623885; DOI=10.1074/jbc.m312205200;
RA Albrecht D.E., Froehner S.C.;
RT "DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin
RT complexes.";
RL J. Biol. Chem. 279:7014-7023(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, Spinal ganglion, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 195-918.
RA Auquier P.H., Chomez P.M., De Backer O.R., Bertrand M.J.M.;
RT "Ten new murine members of the MAGE gene family.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc
CC finger-containing E3 ubiquitin-protein ligases. Proposed to act through
CC recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at
CC the E3:substrate complex (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DTNA. Interacts with TRIM28 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000269|PubMed:14623885}. Nucleus {ECO:0000269|PubMed:14623885}.
CC Cell membrane {ECO:0000269|PubMed:14623885}. Note=In the skeletal
CC muscle, found at the postsynaptic membrane and is associated with a
CC subset of myonuclei. May reside within nuclei and/or in perinuclear
CC compartments. In peripheral nerves, colocalizes with DTNA in the
CC Schwann cell membrane.
CC -!- TISSUE SPECIFICITY: Expressed in cell bodies and dendrites of
CC hippocampal and Purkinje neurons. Also expressed in peripheral nerve,
CC where it localizes to the perineurium and myelin (at protein level).
CC Predominantly expressed in brain and at low levels in the heart, liver,
CC kidney, spleen, testis, lung, thymus, placenta and skeletal muscle.
CC {ECO:0000269|PubMed:14623885}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26750.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC34694.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC38206.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EDL14072.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK030032; BAC26750.1; ALT_INIT; mRNA.
DR EMBL; AK051625; BAC34694.1; ALT_FRAME; mRNA.
DR EMBL; AK081378; BAC38206.1; ALT_INIT; mRNA.
DR EMBL; AL672248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466564; EDL14072.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC059039; AAH59039.1; -; mRNA.
DR EMBL; AF319978; AAK01206.1; -; mRNA.
DR CCDS; CCDS41094.1; -.
DR RefSeq; NP_444431.3; NM_053201.4.
DR AlphaFoldDB; Q6PCZ4; -.
DR SMR; Q6PCZ4; -.
DR BioGRID; 223366; 1.
DR IntAct; Q6PCZ4; 1.
DR STRING; 10090.ENSMUSP00000094078; -.
DR iPTMnet; Q6PCZ4; -.
DR PhosphoSitePlus; Q6PCZ4; -.
DR EPD; Q6PCZ4; -.
DR MaxQB; Q6PCZ4; -.
DR PaxDb; Q6PCZ4; -.
DR PRIDE; Q6PCZ4; -.
DR ProteomicsDB; 287297; -.
DR Antibodypedia; 560; 68 antibodies from 20 providers.
DR DNASU; 107528; -.
DR Ensembl; ENSMUST00000033578; ENSMUSP00000094078; ENSMUSG00000031227.
DR GeneID; 107528; -.
DR KEGG; mmu:107528; -.
DR UCSC; uc009uav.1; mouse.
DR CTD; 57692; -.
DR MGI; MGI:2148149; Magee1.
DR VEuPathDB; HostDB:ENSMUSG00000031227; -.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000163182; -.
DR HOGENOM; CLU_012911_0_0_1; -.
DR InParanoid; Q6PCZ4; -.
DR OMA; CTPVEYE; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; Q6PCZ4; -.
DR TreeFam; TF328505; -.
DR BioGRID-ORCS; 107528; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Magee1; mouse.
DR PRO; PR:Q6PCZ4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6PCZ4; protein.
DR Bgee; ENSMUSG00000031227; Expressed in dorsomedial nucleus of hypothalamus and 186 other tissues.
DR Genevisible; Q6PCZ4; MM.
DR GO; GO:0030425; C:dendrite; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0045211; C:postsynaptic membrane; IDA:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 2.
DR Gene3D; 1.10.10.1210; -; 2.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 5.
DR Pfam; PF01454; MAGE; 1.
DR SMART; SM01373; MAGE; 2.
DR PROSITE; PS50838; MAGE; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Membrane; Nucleus; Reference proteome; Repeat;
KW Tumor antigen; Ubl conjugation pathway.
FT CHAIN 1..918
FT /note="Melanoma-associated antigen E1"
FT /id="PRO_0000404299"
FT DOMAIN 459..658
FT /note="MAGE 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT DOMAIN 706..897
FT /note="MAGE 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..918
FT /note="Interaction with DTNA"
FT /evidence="ECO:0000269|PubMed:14623885"
FT COMPBIAS 71..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 65
FT /note="G -> V (in Ref. 2; BAC34694)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="M -> V (in Ref. 2; BAC26750/BAC38206 and 4;
FT EDL14072)"
FT /evidence="ECO:0000305"
FT CONFLICT 497
FT /note="F -> Y (in Ref. 6; AAK01206)"
FT /evidence="ECO:0000305"
FT CONFLICT 505
FT /note="A -> P (in Ref. 6; AAK01206)"
FT /evidence="ECO:0000305"
FT CONFLICT 584
FT /note="R -> K (in Ref. 6; AAK01206)"
FT /evidence="ECO:0000305"
FT CONFLICT 799
FT /note="L -> F (in Ref. 2; BAC34694)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 918 AA; 101632 MW; C843A36231C2496E CRC64;
MSLVSQNSRR RRGGRANARR NNGKGHPAAV PGPDVPRDRN DPKILQGLRA SEGPGTSMLP
TPREGPSASV PPTASEGSSA PRQFIISQGP NTSEMPTSRK GRGASRPPAV SAGLNTAMSI
TASEGPNSPV PPTAPKGSKA YEHLPVSEGL AISEQRHSDG GPNMEPTLGE GPGISVPPTF
SEESGISDEG LSIFMSPNIS EGPGINEPYS VSEDPSTSVP PTDSNGLGIN LPPTFGEGLS
ISMLFSALEE PDIFAPPPSA EGLFASMSPP SGEIQSSWVS PIIMEGCNVN VPPTSKKGLR
TSVPSAACES PSTSAEGLSS SLSSISAEGF CSSLAPCAAE GSCELLPCGE GRSTSELHCL
GEGSSTSQMS LAAEGPSASG MPTEANNPEE ALSCCASERR NKSTSRALQK AKDPSVRPKR
EDRFLDFQVL RDSKNSNSIT IMGLGTSRVA LTLKPQDPME QNVAELLQFL LLKDQTKYPI
KESDMREFID KDYRHQFPEI LRRAAVHLEC IFRFELKELD TEEHIYILLN KLGPVPFEGL
EDVPNGPKMG LLMMILGHIL LNGNQAREAD IWEMLWRFGV QRERRLSVFG NVKRLLSVEF
VWQRYLDYRP LTDCVPVEYE FYWGPRSRAE TTKMKILKFM AKIYNKDPMD WPALYNEALE
EDADRVVVNN FRVARPFRRP LFAEVAPELD ASGSKYSPHS WPESRLESKA RKLVQLFLLM
DSTKLPIPKK GILYYIGREC TKVFPDLLNR AARTLNHVYG TELVVLDPRN HSYTLYNRRE
MEDTEEIMDS PNRPGNNFLM QVLSFIFIMG NHARESAVWA FLRGLGVQNG RKHVITCRYL
SQRYLDSLRV PDSDPVQYDF VWGPRARLET SKMKALRYVA RIHRKEPEDW PEQYREAMED
EANRAEAGRR PLIVRNLR
