MAGE1_RAT
ID MAGE1_RAT Reviewed; 933 AA.
AC A1A5P9;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Melanoma-associated antigen E1;
DE AltName: Full=Alpha-dystrobrevin-associated MAGE Protein;
DE Short=DAMAGE;
DE AltName: Full=MAGE-E1 antigen;
GN Name=Magee1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May enhance ubiquitin ligase activity of RING-type zinc
CC finger-containing E3 ubiquitin-protein ligases. Proposed to act through
CC recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at
CC the E3:substrate complex (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DTNA. Interacts with TRIM28. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=In the
CC skeletal muscle, found at the postsynaptic membrane and is associated
CC with a subset of myonuclei. May reside within nuclei and/or in
CC perinuclear compartments. In peripheral nerves, colocalizes with DTNA
CC in the Schwann cell membrane (By similarity). {ECO:0000250}.
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DR EMBL; CH473969; EDM07152.1; -; Genomic_DNA.
DR EMBL; BC128754; AAI28755.1; -; mRNA.
DR RefSeq; NP_001073360.1; NM_001079891.1.
DR AlphaFoldDB; A1A5P9; -.
DR SMR; A1A5P9; -.
DR BioGRID; 261486; 1.
DR STRING; 10116.ENSRNOP00000054396; -.
DR iPTMnet; A1A5P9; -.
DR PhosphoSitePlus; A1A5P9; -.
DR PaxDb; A1A5P9; -.
DR Ensembl; ENSRNOT00000003573; ENSRNOP00000054396; ENSRNOG00000002660.
DR GeneID; 317232; -.
DR KEGG; rno:317232; -.
DR UCSC; RGD:1560259; rat.
DR CTD; 57692; -.
DR RGD; 1560259; Magee1.
DR eggNOG; KOG4562; Eukaryota.
DR GeneTree; ENSGT00940000163182; -.
DR HOGENOM; CLU_012911_0_0_1; -.
DR InParanoid; A1A5P9; -.
DR OMA; CTPVEYE; -.
DR OrthoDB; 1195799at2759; -.
DR PhylomeDB; A1A5P9; -.
DR PRO; PR:A1A5P9; -.
DR Proteomes; UP000002494; Chromosome X.
DR Proteomes; UP000234681; Chromosome x.
DR Bgee; ENSRNOG00000002660; Expressed in Ammon's horn and 19 other tissues.
DR Genevisible; A1A5P9; RN.
DR GO; GO:0030425; C:dendrite; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0045211; C:postsynaptic membrane; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1200; -; 2.
DR Gene3D; 1.10.10.1210; -; 2.
DR InterPro; IPR037445; MAGE.
DR InterPro; IPR041898; MAGE_WH1.
DR InterPro; IPR041899; MAGE_WH2.
DR InterPro; IPR002190; MHD_dom.
DR PANTHER; PTHR11736; PTHR11736; 5.
DR Pfam; PF01454; MAGE; 1.
DR SMART; SM01373; MAGE; 2.
DR PROSITE; PS50838; MAGE; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Membrane; Nucleus; Reference proteome; Repeat;
KW Tumor antigen; Ubl conjugation pathway.
FT CHAIN 1..933
FT /note="Melanoma-associated antigen E1"
FT /id="PRO_0000404300"
FT DOMAIN 467..666
FT /note="MAGE 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT DOMAIN 721..912
FT /note="MAGE 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..933
FT /note="Interaction with DTNA"
FT /evidence="ECO:0000250"
FT COMPBIAS 60..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 933 AA; 102181 MW; 51060923ECC9A7C3 CRC64;
MSLVSQNSRR RRGGRANGRK NSGKGRPAAV PGPAVPRDRS DPQILQGLGA TEGPGTSVLP
TPRGGSSTSV PPTASEGSSA PGQLITSEGR NTSQLPTSRK GRGTRRPPAV SAGLNAAASI
TASEGASTPV LPTAPKGSKA SEHLTISEGA SISEQPQSHE GPNVQPTLGE GSGTSVPPTF
SEESGISEPL PSGEGLSISV SPTISEGAGI NEPSPASKAP STSVPPTASN GLGINLPPTS
SEGLSISVLF SASEESDISV PPPSAEGLST SMPPPSGEVQ STWVPPIILE GCSVKVRSTS
RKGRRTPVRS AACESPSPSA ECLSTSLSSI SAEGFCSSLA PCAEGSDTCE LLPCGEGPST
SGLHDLEEES SISQMPLAAE GPSASGSSIE DENPEEALSC GASVGMNLCK CTSLALQKAD
DPSVRPKRAE GFLDFQVLRD SENSNSITIM GLGTAHVALT LKPQDPMEQN VAELLQFLLL
KDQTKYPIKE SEMREFIVQE YRNQFPEILR RAAAHLECIF RFELKELDPE EHTYILLNKL
GPVPFEGLED IPNGPKMGLL MMILGQIFLN GNQAREADIW EMLWRFGVQR ERRLSVFGNP
KRLLSVEFVW QRYLDYRPIT DCVPVEYEFY WGPRSHVETT KMKILKFMAR IYNKDPMDWP
AQYNEALEEE AERDVPNNWR AVPHFRRPLF QEVSPELLAS DSDAPGCPSK YSPHSWPESR
LESKSRKLVQ LFLLMDSTKL PIPKKGILYY IGRECSKVFP DLLNRAARTL NHVYGTELVV
LDPRNHSYTL YNRREMEDME EIMDSPNRPG NNFLMQVLSF IFIMGNHARE SAVWAFLRGL
GVQNGRKHVI TCRYLSQRYI DSLRVPDSDP VQYDFVWGPR ARLETSKMKA LRYVARIHRK
EPQDWPDQYR EALEDEANRA EAGRRPLVVR NLR
