ID   MAGE2_HUMAN             Reviewed;         523 AA.
AC   Q8TD90; Q5JSI5;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Melanoma-associated antigen E2;
DE   AltName: Full=Hepatocellular carcinoma-associated protein 3;
DE   AltName: Full=MAGE-E2 antigen;
GN   Name=MAGEE2; Synonyms=HCA3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Dong X.-Y., Chen W.-F.;
RT   "Identification of genes in the chromosome X that are differentially
RT   expressed in hepatocellular carcinoma.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AF490509; AAM08356.1; -; mRNA.
DR   EMBL; AK094624; BAC04387.1; -; mRNA.
DR   EMBL; AL391495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC093964; AAH93964.1; -; mRNA.
DR   EMBL; BC111949; AAI11950.1; -; mRNA.
DR   CCDS; CCDS14431.1; -.
DR   RefSeq; NP_619648.1; NM_138703.4.
DR   AlphaFoldDB; Q8TD90; -.
DR   SMR; Q8TD90; -.
DR   BioGRID; 126577; 43.
DR   IntAct; Q8TD90; 5.
DR   MINT; Q8TD90; -.
DR   STRING; 9606.ENSP00000362457; -.
DR   BioMuta; MAGEE2; -.
DR   EPD; Q8TD90; -.
DR   jPOST; Q8TD90; -.
DR   PaxDb; Q8TD90; -.
DR   PeptideAtlas; Q8TD90; -.
DR   PRIDE; Q8TD90; -.
DR   ProteomicsDB; 74251; -.
DR   Antibodypedia; 28084; 81 antibodies from 21 providers.
DR   DNASU; 139599; -.
DR   Ensembl; ENST00000373359.4; ENSP00000362457.2; ENSG00000186675.7.
DR   GeneID; 139599; -.
DR   KEGG; hsa:139599; -.
DR   MANE-Select; ENST00000373359.4; ENSP00000362457.2; NM_138703.5; NP_619648.1.
DR   UCSC; uc004ecj.3; human.
DR   CTD; 139599; -.
DR   DisGeNET; 139599; -.
DR   GeneCards; MAGEE2; -.
DR   HGNC; HGNC:24935; MAGEE2.
DR   HPA; ENSG00000186675; Tissue enhanced (brain).
DR   MIM; 300760; gene.
DR   neXtProt; NX_Q8TD90; -.
DR   OpenTargets; ENSG00000186675; -.
DR   PharmGKB; PA134923697; -.
DR   VEuPathDB; HostDB:ENSG00000186675; -.
DR   eggNOG; KOG4562; Eukaryota.
DR   GeneTree; ENSGT00940000163487; -.
DR   HOGENOM; CLU_039515_0_0_1; -.
DR   InParanoid; Q8TD90; -.
DR   OMA; DEPQRIN; -.
DR   OrthoDB; 1195799at2759; -.
DR   PhylomeDB; Q8TD90; -.
DR   TreeFam; TF328505; -.
DR   PathwayCommons; Q8TD90; -.
DR   SignaLink; Q8TD90; -.
DR   BioGRID-ORCS; 139599; 3 hits in 681 CRISPR screens.
DR   GenomeRNAi; 139599; -.
DR   Pharos; Q8TD90; Tdark.
DR   PRO; PR:Q8TD90; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q8TD90; protein.
DR   Bgee; ENSG00000186675; Expressed in endothelial cell and 72 other tissues.
DR   Genevisible; Q8TD90; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1200; -; 2.
DR   Gene3D; 1.10.10.1210; -; 2.
DR   InterPro; IPR037445; MAGE.
DR   InterPro; IPR041898; MAGE_WH1.
DR   InterPro; IPR041899; MAGE_WH2.
DR   InterPro; IPR002190; MHD_dom.
DR   PANTHER; PTHR11736; PTHR11736; 4.
DR   Pfam; PF01454; MAGE; 1.
DR   SMART; SM01373; MAGE; 2.
DR   PROSITE; PS50838; MAGE; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Tumor antigen.
FT   CHAIN           1..523
FT                   /note="Melanoma-associated antigen E2"
FT                   /id="PRO_0000156731"
FT   DOMAIN          88..288
FT                   /note="MAGE 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   DOMAIN          311..502
FT                   /note="MAGE 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00127"
FT   VARIANT         291
FT                   /note="G -> C (in dbSNP:rs12688600)"
FT                   /id="VAR_053509"
SQ   SEQUENCE   523 AA;  60378 MW;  FB668B47A2B72AFB CRC64;
     MSLVSQNARH CSAEITADYG DGRGEIQATN ASGSPTSMLV VDAPQCPQAP INSQCVNTSQ
     AVQDPNDLEV LIDEQSRRLG ALRVHDPLED RSIALVNFMR MKSQTEGSIQ QSEMLEFLRE
     YSDQFPEILR RASAHLDQVF GLNLRVIDPQ ADTYNLVSKR GFQITDRIAE SLDMPKASLL
     ALVLGHILLN GNRAREASIW DLLLKVDMWD KPQRINNLFG NTRNLLTTDF VCMRFLEYWP
     VYGTNPLEFE FLWGSRAHRE ITKMEALKFV SDAHDEEPWS WPEEYNKALE GDKTKERSLT
     AGLEFWSEDT MNDKANDLVQ LAISVTEEML PIHQDELLAH TGKEFEDVFP NILNRATLIL
     DMFYGLSLIE VDTSEHIYLL VQQPESEEEQ VMLESLGRPT QEYVMPILGL IFLMGNRVKE
     ANVWNLLRRF SVDVGRKHSI TRKLMRQRYL ECRPLSYSNP VEYELLWGPR AHHETIKMKV
     LEYMARLYRK RPQNWPEQYR EAVEDEEARA KSEATIMFFL DPT