MAGIX_HUMAN
ID MAGIX_HUMAN Reviewed; 334 AA.
AC Q9H6Y5; A0A075B7A2; A6XND4; A8MSX9; B7WP26; Q14C81;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=PDZ domain-containing protein MAGIX;
GN Name=MAGIX;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RA Yu Z., Zheng Z., Tang T., Fu Y.;
RT "A computer system platform used to predict novel genes.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [6]
RP STRUCTURE BY NMR OF 59-150.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structures of the PDZ domain of human unnamed protein product.";
RL Submitted (OCT-2006) to the PDB data bank.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9H6Y5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6Y5-2; Sequence=VSP_029319;
CC Name=3;
CC IsoId=Q9H6Y5-3; Sequence=VSP_029319, VSP_029320;
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DR EMBL; DQ884401; ABI63368.1; -; mRNA.
DR EMBL; AK025340; BAB15115.1; -; mRNA.
DR EMBL; AC231657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF196779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471224; EAW50691.1; -; Genomic_DNA.
DR CCDS; CCDS48106.1; -. [Q9H6Y5-1]
DR RefSeq; NP_001093151.2; NM_001099681.2.
DR RefSeq; NP_001093152.2; NM_001099682.2.
DR RefSeq; NP_079135.3; NM_024859.3. [Q9H6Y5-1]
DR RefSeq; XP_005278121.1; XM_005278064.4. [Q9H6Y5-2]
DR RefSeq; XP_005278122.1; XM_005278065.3. [Q9H6Y5-2]
DR RefSeq; XP_011542287.1; XM_011543985.2. [Q9H6Y5-2]
DR RefSeq; XP_011542288.1; XM_011543986.2. [Q9H6Y5-2]
DR RefSeq; XP_011542289.1; XM_011543987.2. [Q9H6Y5-2]
DR PDB; 2DJT; NMR; -; A=119-209.
DR PDBsum; 2DJT; -.
DR AlphaFoldDB; Q9H6Y5; -.
DR SMR; Q9H6Y5; -.
DR BioGRID; 122995; 36.
DR IntAct; Q9H6Y5; 23.
DR STRING; 9606.ENSP00000471299; -.
DR iPTMnet; Q9H6Y5; -.
DR PhosphoSitePlus; Q9H6Y5; -.
DR BioMuta; MAGIX; -.
DR DMDM; 209572736; -.
DR jPOST; Q9H6Y5; -.
DR MassIVE; Q9H6Y5; -.
DR PaxDb; Q9H6Y5; -.
DR PeptideAtlas; Q9H6Y5; -.
DR PRIDE; Q9H6Y5; -.
DR ProteomicsDB; 81059; -. [Q9H6Y5-1]
DR ProteomicsDB; 81060; -. [Q9H6Y5-2]
DR ProteomicsDB; 81061; -. [Q9H6Y5-3]
DR Antibodypedia; 72948; 64 antibodies from 15 providers.
DR DNASU; 79917; -.
DR Ensembl; ENST00000595224.5; ENSP00000471299.1; ENSG00000269313.5. [Q9H6Y5-1]
DR Ensembl; ENST00000616266.4; ENSP00000481198.1; ENSG00000269313.5. [Q9H6Y5-2]
DR GeneID; 79917; -.
DR KEGG; hsa:79917; -.
DR MANE-Select; ENST00000595224.6; ENSP00000471299.1; NM_024859.4; NP_079135.3.
DR CTD; 79917; -.
DR GeneCards; MAGIX; -.
DR HGNC; HGNC:30006; MAGIX.
DR HPA; ENSG00000269313; Tissue enhanced (liver).
DR neXtProt; NX_Q9H6Y5; -.
DR OpenTargets; ENSG00000269313; -.
DR PharmGKB; PA162394882; -.
DR VEuPathDB; HostDB:ENSG00000269313; -.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000162529; -.
DR InParanoid; Q9H6Y5; -.
DR OMA; VDHRPQH; -.
DR OrthoDB; 284488at2759; -.
DR PhylomeDB; Q9H6Y5; -.
DR TreeFam; TF315536; -.
DR PathwayCommons; Q9H6Y5; -.
DR SignaLink; Q9H6Y5; -.
DR BioGRID-ORCS; 79917; 10 hits in 680 CRISPR screens.
DR EvolutionaryTrace; Q9H6Y5; -.
DR GenomeRNAi; 79917; -.
DR Pharos; Q9H6Y5; Tdark.
DR PRO; PR:Q9H6Y5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9H6Y5; protein.
DR Bgee; ENSG00000269313; Expressed in right lobe of liver and 103 other tissues.
DR ExpressionAtlas; Q9H6Y5; baseline and differential.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR030031; MAGIX.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR47646; PTHR47646; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..334
FT /note="PDZ domain-containing protein MAGIX"
FT /id="PRO_0000310542"
FT DOMAIN 125..209
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 272
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4KL35"
FT VAR_SEQ 1..92
FT /note="MEPRTGDAADPRGSRGGRGPSPLAGPSARQLLARLDARPLAARAAVDVAALV
FT RRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRP -> MPLLWITGPRYHLIL
FT LSEASCLRANYVHLCPLF (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_029319"
FT VAR_SEQ 227..231
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_029320"
FT VARIANT 53
FT /note="R -> H (in dbSNP:rs5906744)"
FT /id="VAR_037075"
FT VARIANT 112
FT /note="R -> H (in dbSNP:rs5906744)"
FT /id="VAR_047035"
FT VARIANT 173
FT /note="L -> V (in dbSNP:rs5905720)"
FT /id="VAR_047036"
FT VARIANT 323
FT /note="L -> F (in dbSNP:rs4824462)"
FT /id="VAR_047037"
FT STRAND 124..129
FT /evidence="ECO:0007829|PDB:2DJT"
FT STRAND 132..134
FT /evidence="ECO:0007829|PDB:2DJT"
FT STRAND 137..140
FT /evidence="ECO:0007829|PDB:2DJT"
FT STRAND 152..156
FT /evidence="ECO:0007829|PDB:2DJT"
FT HELIX 161..165
FT /evidence="ECO:0007829|PDB:2DJT"
FT STRAND 173..177
FT /evidence="ECO:0007829|PDB:2DJT"
FT HELIX 187..196
FT /evidence="ECO:0007829|PDB:2DJT"
FT STRAND 199..205
FT /evidence="ECO:0007829|PDB:2DJT"
SQ SEQUENCE 334 AA; 35273 MW; 29F4C19DE64AC790 CRC64;
MEPRTGDAAD PRGSRGGRGP SPLAGPSARQ LLARLDARPL AARAAVDVAA LVRRAGATLR
LRRKEAVSVL DSADIEVTDS RLPHATIVDH RPQHRWLETC NAPPQLIQGK ARSAPKPSQA
SGHFSVELVR GYAGFGLTLG GGRDVAGDTP LAVRGLLKDG PAQRCGRLEV GDLVLHINGE
STQGLTHAQA VERIRAGGPQ LHLVIRRPLE THPGKPRGVG EPRKGVVPSW PDRSPDPGGP
EVTGSRSSST SLVQHPPSRT TLKKTRGSPE PSPEAAADGP TVSPPERRAE DPNDQIPGSP
GPWLVPSEER LSRALGVRGA AQLAQEMAAG RRRH
