MAGIX_MOUSE
ID MAGIX_MOUSE Reviewed; 324 AA.
AC Q4KL35; Q9JIG3;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=PDZ domain-containing protein MAGIX;
GN Name=Magix; Synonyms=Pdzx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10857745; DOI=10.1006/geno.2000.6173;
RA Means G.D., Toy D.Y., Baum P.R., Derry J.M.J.;
RT "A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse
RT X chromosome and regional mapping of the scurfy mutation.";
RL Genomics 65:213-223(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF229645; AAF66955.1; -; mRNA.
DR EMBL; AL672231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC099459; AAH99459.1; -; mRNA.
DR EMBL; BC132580; AAI32581.1; -; mRNA.
DR EMBL; BC132582; AAI32583.1; -; mRNA.
DR CCDS; CCDS29968.1; -.
DR RefSeq; NP_061302.2; NM_018832.2.
DR AlphaFoldDB; Q4KL35; -.
DR STRING; 10090.ENSMUSP00000111359; -.
DR iPTMnet; Q4KL35; -.
DR PhosphoSitePlus; Q4KL35; -.
DR MaxQB; Q4KL35; -.
DR PaxDb; Q4KL35; -.
DR PRIDE; Q4KL35; -.
DR ProteomicsDB; 292002; -.
DR Antibodypedia; 72948; 64 antibodies from 15 providers.
DR DNASU; 54634; -.
DR Ensembl; ENSMUST00000115695; ENSMUSP00000111359; ENSMUSG00000031147.
DR GeneID; 54634; -.
DR KEGG; mmu:54634; -.
DR UCSC; uc009sly.1; mouse.
DR CTD; 79917; -.
DR MGI; MGI:1859644; Magix.
DR VEuPathDB; HostDB:ENSMUSG00000031147; -.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000162529; -.
DR HOGENOM; CLU_076904_0_0_1; -.
DR InParanoid; Q4KL35; -.
DR OMA; VDHRPQH; -.
DR OrthoDB; 284488at2759; -.
DR PhylomeDB; Q4KL35; -.
DR TreeFam; TF315536; -.
DR BioGRID-ORCS; 54634; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Magix; mouse.
DR PRO; PR:Q4KL35; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q4KL35; protein.
DR Bgee; ENSMUSG00000031147; Expressed in hindlimb stylopod muscle and 54 other tissues.
DR Genevisible; Q4KL35; MM.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR030031; MAGIX.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR47646; PTHR47646; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..324
FT /note="PDZ domain-containing protein MAGIX"
FT /id="PRO_0000310543"
FT DOMAIN 128..212
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 261
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT CONFLICT 113
FT /note="K -> M (in Ref. 1; AAF66955)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 34771 MW; 13B19322743B9736 CRC64;
MDSRAGNTAD PRGGRRGGGL QGSRSPRARQ LLERLDARPL AARAAADLTA LVRKAGATLR
LRHTEGVSGL DSADIEVTDS RLPHATLVKH RPQHQRSETL GTWTEPLPVT QNKASYALKV
PQATGRFSVE LTRGPAGFGL TLSGGRNVSG DAPLTVHGLL KDGPAQRCGR LQAGDLVLYI
NGQSTQGLTH AQVVERIRTG GPHLCLVLQR PQDMDGSRIK EVGGHRKTDR SLDPRGSRVE
SRSTISPVHH RPKTRTSPRP SPEAVAIGHV VRAVEHPTED LENRIPGTPG PWLVPSEDRL
SRALGVRGGG AQLALEMAAG RRRH
