MAHS_RAMVA
ID MAHS_RAMVA Reviewed; 236 AA.
AC A0A1D1V3Z0; A0A0E4FH01;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2017, sequence version 2.
DT 25-MAY-2022, entry version 11.
DE RecName: Full=Mitochondrial-abundant heat soluble protein {ECO:0000303|PubMed:25675104};
DE Short=MAHS {ECO:0000303|PubMed:25675104};
DE Flags: Precursor;
GN Name=MAHS {ECO:0000303|PubMed:25675104}; ORFNames=RvY_05157;
OS Ramazzottius varieornatus (Water bear) (Tardigrade).
OC Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC Hypsibioidea; Ramazzottiidae; Ramazzottius.
OX NCBI_TaxID=947166;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND DOMAIN.
RC STRAIN=YOKOZUNA-1;
RX PubMed=25675104; DOI=10.1371/journal.pone.0118272;
RA Tanaka S., Tanaka J., Miwa Y., Horikawa D.D., Katayama T., Arakawa K.,
RA Toyoda A., Kubo T., Kunieda T.;
RT "Novel mitochondria-targeted heat-soluble proteins identified in the
RT anhydrobiotic Tardigrade improve osmotic tolerance of human cells.";
RL PLoS ONE 10:E0118272-E0118272(2015).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YOKOZUNA-1;
RX PubMed=27649274; DOI=10.1038/ncomms12808;
RA Hashimoto T., Horikawa D.D., Saito Y., Kuwahara H., Kozuka-Hata H.,
RA Shin-I T., Minakuchi Y., Ohishi K., Motoyama A., Aizu T., Enomoto A.,
RA Kondo K., Tanaka S., Hara Y., Koshikawa S., Sagara H., Miura T.,
RA Yokobori S., Miyagawa K., Suzuki Y., Kubo T., Oyama M., Kohara Y.,
RA Fujiyama A., Arakawa K., Katayama T., Toyoda A., Kunieda T.;
RT "Extremotolerant tardigrade genome and improved radiotolerance of human
RT cultured cells by tardigrade-unique protein.";
RL Nat. Commun. 7:12808-12808(2016).
CC -!- FUNCTION: Mitochondrial heat soluble protein acting as a molecular
CC shield in water-deficient condition. {ECO:0000269|PubMed:25675104}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25675104}.
CC -!- DOMAIN: The MAHS motif is conserved in tardigrade MAHS proteins and
CC forms a predicted amphipathic helix (PubMed:25675104).
CC {ECO:0000305|PubMed:25675104}.
CC -!- MISCELLANEOUS: Improves osmotic tolerance of human cells
CC (PubMed:25675104). {ECO:0000269|PubMed:25675104}.
CC -!- SEQUENCE CAUTION:
CC Sequence=GAU93178.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; LC002822; BAQ94587.1; -; mRNA.
DR EMBL; BDGG01000002; GAU93178.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; A0A1D1V3Z0; -.
DR Proteomes; UP000186922; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Stress response; Transit peptide.
FT TRANSIT 1..73
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 74..236
FT /note="Mitochondrial-abundant heat soluble protein"
FT /id="PRO_0000440200"
FT REGION 102..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 126..143
FT /note="MAHS motif"
FT /evidence="ECO:0000305|PubMed:25675104"
FT COMPBIAS 102..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 25410 MW; 610C20421A42CA91 CRC64;
MSRYLLRDVQ AVLRGVRKVA ESSLKLETEK VSLRLGDFRS QPSLRSVPAS LTSRSQAFSL
QEIAARAGVV LRGVQQQFRN VTGVNAAPVV AFDNGSVLYS ERIHSQSSQK QAPTTVPTGS
VSNSPQPEGK ANEAAERAKQ FMNPPVAPMD PVDKNEFVAM PEMGRSNGNG ENKQAADFMK
NQGDTDMDSQ YAPDSSKNTK SVPTKEIVAE DGSMSIEDIK KATQVTPGVA VKNEGV
