ID   MAIL1_ARATH             Reviewed;         509 AA.
AC   Q9SK32; Q0WN90; Q8LFH9;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein MAIN-LIKE 1 {ECO:0000303|PubMed:24635680};
GN   Name=MAIL1 {ECO:0000303|PubMed:24635680};
GN   OrderedLocusNames=At2g25010 {ECO:0000312|Araport:AT2G25010};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=24635680; DOI=10.1111/tpj.12455;
RA   Uehlken C., Horvath B., Stadler R., Sauer N., Weingartner M.;
RT   "MAIN-LIKE1 is a crucial factor for correct cell division and
RT   differentiation in Arabidopsis thaliana.";
RL   Plant J. 78:107-120(2014).
CC   -!- FUNCTION: Acts as an important factor for cell fate determination and
CC       maintenance throughout plant development. Required for the organization
CC       of the root apical meristem (RAM) and the shoot apical meristem (SAM).
CC       Required to maintain genome stability and cell division activity in
CC       meristematic cells. {ECO:0000269|PubMed:24635680}.
CC   -!- INTERACTION:
CC       Q9SK32; Q9SVQ1: YUC2; NbExp=4; IntAct=EBI-25510817, EBI-25510831;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24635680}.
CC   -!- TISSUE SPECIFICITY: Expressed in root tips, the shoot apical meristem
CC       (SAM), leaves, mature flowers and embryos.
CC       {ECO:0000269|PubMed:24635680}.
CC   -!- DISRUPTION PHENOTYPE: Strong developmental phenotypes, such as
CC       extremely short, and agravitropic primary roots, small aerial organ
CC       size, altered shape and pale white leaves, bushy inflorescence and
CC       reduced number of seeds. {ECO:0000269|PubMed:24635680}.
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DR   EMBL; AC006585; AAD23012.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC07649.1; -; Genomic_DNA.
DR   EMBL; BT025335; ABF57291.1; -; mRNA.
DR   EMBL; AK229557; BAF01410.1; -; mRNA.
DR   EMBL; AY084833; AAM61398.1; -; mRNA.
DR   PIR; B84643; B84643.
DR   RefSeq; NP_565582.1; NM_128059.5.
DR   AlphaFoldDB; Q9SK32; -.
DR   IntAct; Q9SK32; 1.
DR   STRING; 3702.AT2G25010.1; -.
DR   PaxDb; Q9SK32; -.
DR   PRIDE; Q9SK32; -.
DR   ProteomicsDB; 239038; -.
DR   EnsemblPlants; AT2G25010.1; AT2G25010.1; AT2G25010.
DR   GeneID; 817040; -.
DR   Gramene; AT2G25010.1; AT2G25010.1; AT2G25010.
DR   KEGG; ath:AT2G25010; -.
DR   Araport; AT2G25010; -.
DR   TAIR; locus:2047339; AT2G25010.
DR   eggNOG; ENOG502QW7G; Eukaryota.
DR   HOGENOM; CLU_028845_3_0_1; -.
DR   InParanoid; Q9SK32; -.
DR   OMA; GRCKNAV; -.
DR   OrthoDB; 268946at2759; -.
DR   PhylomeDB; Q9SK32; -.
DR   PRO; PR:Q9SK32; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SK32; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:0010073; P:meristem maintenance; IMP:TAIR.
DR   GO; GO:0010082; P:regulation of root meristem growth; IMP:TAIR.
DR   InterPro; IPR019557; AminoTfrase-like_pln_mobile.
DR   InterPro; IPR044824; MAIN-like.
DR   PANTHER; PTHR46033; PTHR46033; 1.
DR   Pfam; PF10536; PMD; 1.
PE   1: Evidence at protein level;
KW   Aminotransferase; Developmental protein; Growth regulation; Nucleus;
KW   Reference proteome; Transferase.
FT   CHAIN           1..509
FT                   /note="Protein MAIN-LIKE 1"
FT                   /id="PRO_0000438663"
FT   REGION          477..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        80
FT                   /note="V -> A (in Ref. 4; BAF01410)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        123
FT                   /note="G -> D (in Ref. 5; AAM61398)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   509 AA;  57481 MW;  3EEE1C7323B5B0F7 CRC64;
     MDIDVGPVDP SVLYEQDLHV SSAVWEGQER GLLRCQEHTS LLHQWKLTDE QINLVDKAGF
     GYFRKIGPMS LNNSLISALV ERWRRETNTF HLPLGEMTIT LDEVALVLGL EIDGDPIVGS
     KVGDEVAMDM CGRLLGKLPS AANKEVNCSR VKLNWLKRTF SECPEDASFD VVKCHTRAYL
     LYLIGSTIFA TTDGDKVSVK YLPLFEDFDQ AGRYAWGAAA LACLYRALGN ASLKSQSNIC
     GCLTLLQCWS YFHLDIGRPE KSEACFPLAL LWKGKGSRSK TDLSEYRREL DDLDPSKITW
     CPYERFENLI PPHIKAKLIL GRSKTTLVCF EKIELHFPDR CLRQFGKRQP IPLKVKRRDR
     KNRRLDDLDT SMSLACEEWA ERGDHIVDSP GGGNVVDDGA YMEWYARISI TKLYREAFLE
     SQVMNMIACM REFEEAASGI ALERLSPAER EVMESVKDTF ANSLTFGGWQ EVAVNSGYGK
     RRRRNEHTPT PNNGGGNDIS SLLLQKEDS