MAIL2_ARATH
ID MAIL2_ARATH Reviewed; 667 AA.
AC F4IFD0;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Protein MAIN-LIKE 2 {ECO:0000303|PubMed:24635680};
GN OrderedLocusNames=At2g04865 {ECO:0000312|Araport:AT2G04865};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [5]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=24635680; DOI=10.1111/tpj.12455;
RA Uehlken C., Horvath B., Stadler R., Sauer N., Weingartner M.;
RT "MAIN-LIKE1 is a crucial factor for correct cell division and
RT differentiation in Arabidopsis thaliana.";
RL Plant J. 78:107-120(2014).
CC -!- FUNCTION: Maybe required to maintain cell division activity in
CC meristematic cells. {ECO:0000250|UniProtKB:Q9LMT7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24635680}.
CC -!- TISSUE SPECIFICITY: Expressed in root tips, the shoot apical meristem
CC (SAM), leaves, mature flowers and embryos.
CC {ECO:0000269|PubMed:24635680}.
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DR EMBL; AC006955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; AEC05878.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM63196.1; -; Genomic_DNA.
DR RefSeq; NP_001325301.1; NM_001335267.1.
DR RefSeq; NP_671779.1; NM_147246.3.
DR AlphaFoldDB; F4IFD0; -.
DR STRING; 3702.AT2G04865.1; -.
DR iPTMnet; F4IFD0; -.
DR PaxDb; F4IFD0; -.
DR PRIDE; F4IFD0; -.
DR ProteomicsDB; 238865; -.
DR EnsemblPlants; AT2G04865.1; AT2G04865.1; AT2G04865.
DR EnsemblPlants; AT2G04865.2; AT2G04865.2; AT2G04865.
DR GeneID; 815033; -.
DR Gramene; AT2G04865.1; AT2G04865.1; AT2G04865.
DR Gramene; AT2G04865.2; AT2G04865.2; AT2G04865.
DR KEGG; ath:AT2G04865; -.
DR Araport; AT2G04865; -.
DR TAIR; locus:504956030; AT2G04865.
DR eggNOG; ENOG502QW7G; Eukaryota.
DR HOGENOM; CLU_028845_3_1_1; -.
DR InParanoid; F4IFD0; -.
DR OMA; FCDASNE; -.
DR OrthoDB; 268946at2759; -.
DR PRO; PR:F4IFD0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IFD0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0010073; P:meristem maintenance; IEA:InterPro.
DR InterPro; IPR019557; AminoTfrase-like_pln_mobile.
DR InterPro; IPR044824; MAIN-like.
DR PANTHER; PTHR46033; PTHR46033; 1.
DR Pfam; PF10536; PMD; 1.
PE 1: Evidence at protein level;
KW Acetylation; Aminotransferase; Nucleus; Reference proteome; Transferase.
FT CHAIN 1..667
FT /note="Protein MAIN-LIKE 2"
FT /id="PRO_0000438664"
FT REGION 492..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22223895"
SQ SEQUENCE 667 AA; 75509 MW; DEC3DAD20ADCE231 CRC64;
MDVLANPGPL KDIVLYDQEK HVSSAVWDGQ ERGALRCHEH TSKLGEWKLK PKQIELVERA
GFGFLRRIPA ISLDNPLISA LVERWRRETN TFHFTVGEMT VTLEDIALLL GLGIDGKPVI
GLTYTTCSAV CERYLGKSPA SNSASGGMVK LSWLKDNFSE CPDDASFEEV ERRTRAYLLY
LVGSTIFSTT TGNKVPVMYL PLFEDFDDAG TFAWGAAALA FLYRALGNAS VKSQSTICGC
LTLLQCWSYY HLNIGRPKLN REPIHDQFPF VLKWKGKQNG PTANRDVVFY RKALDVMKPT
DVVWLPYENM NGGDMSDRMR KSLLLGRSKT MLISFDKAER HLPDRCRKQF DLFQDIPADV
QRWVRKSRGV DGGVDLSNKM ESELSEWEMR WENIVPDDVQ GVDEADYMRW YLGITRKIVG
RPISLSSEFQ RTISNVRDIL ELAENFQIHD LDLERGNMIS RIIGLAQDCL RDQVGVTATP
ETQQQIELGK RMRGKERVRR KGMGKRRKGI DPMEDYGGSE DESQFGPLVE VGQMHLPLSH
TNSVYDGTHM YDAVTKVDDM ELCDTIPQLP ETQDIHKIEG SLLDDTDKFV EESKLQEEFD
GEEPTESYDV KKEDKESKVE DDDAAKGFSD VSGEENANRE EEDETEMGES VAESSSLDRR
GENTVVA
