MAIN_ARATH
ID MAIN_ARATH Reviewed; 478 AA.
AC Q9LMT7;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein MAINTENANCE OF MERISTEMS {ECO:0000303|PubMed:23607329};
GN Name=MAIN {ECO:0000303|PubMed:23607329};
GN OrderedLocusNames=At1g17930 {ECO:0000312|Araport:AT1G17930};
GN ORFNames=F2H15.15 {ECO:0000312|EMBL:AAF97272.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
RP AND MUTAGENESIS OF 465-ARG--ARG-467.
RX PubMed=23607329; DOI=10.1111/tpj.12215;
RA Wenig U., Meyer S., Stadler R., Fischer S., Werner D., Lauter A.,
RA Melzer M., Hoth S., Weingartner M., Sauer N.;
RT "Identification of MAIN, a factor involved in genome stability in the
RT meristems of Arabidopsis thaliana.";
RL Plant J. 75:469-483(2013).
CC -!- FUNCTION: Required for the organization of the root apical meristem
CC (RAM) and the shoot apical meristem (SAM). Required to maintain genome
CC stability and cell division activity in meristematic cells.
CC {ECO:0000269|PubMed:23607329}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23607329}.
CC -!- TISSUE SPECIFICITY: Expressed in root meristem, root vasculature, shoot
CC apical meristem (SAM), leaf vasculature and ovules.
CC {ECO:0000269|PubMed:23607329}.
CC -!- DISRUPTION PHENOTYPE: Developmental defects, such as short roots,
CC misshaped leaves, reduced fertility and partial fasciation of stems.
CC {ECO:0000269|PubMed:23607329}.
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DR EMBL; AC034106; AAF97272.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29653.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59252.1; -; Genomic_DNA.
DR EMBL; AK221477; BAD94623.1; -; mRNA.
DR PIR; E86314; E86314.
DR RefSeq; NP_001321625.1; NM_001332325.1.
DR RefSeq; NP_564042.1; NM_101656.3.
DR AlphaFoldDB; Q9LMT7; -.
DR STRING; 3702.AT1G17930.1; -.
DR iPTMnet; Q9LMT7; -.
DR PaxDb; Q9LMT7; -.
DR PRIDE; Q9LMT7; -.
DR ProteomicsDB; 238230; -.
DR EnsemblPlants; AT1G17930.1; AT1G17930.1; AT1G17930.
DR EnsemblPlants; AT1G17930.2; AT1G17930.2; AT1G17930.
DR GeneID; 838372; -.
DR Gramene; AT1G17930.1; AT1G17930.1; AT1G17930.
DR Gramene; AT1G17930.2; AT1G17930.2; AT1G17930.
DR KEGG; ath:AT1G17930; -.
DR Araport; AT1G17930; -.
DR TAIR; locus:2030878; AT1G17930.
DR eggNOG; ENOG502QW7G; Eukaryota.
DR HOGENOM; CLU_028845_3_0_1; -.
DR InParanoid; Q9LMT7; -.
DR OMA; HRSEHIW; -.
DR OrthoDB; 268946at2759; -.
DR PhylomeDB; Q9LMT7; -.
DR PRO; PR:Q9LMT7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LMT7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0048507; P:meristem development; IMP:TAIR.
DR GO; GO:0010073; P:meristem maintenance; IEA:InterPro.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR019557; AminoTfrase-like_pln_mobile.
DR InterPro; IPR044824; MAIN-like.
DR PANTHER; PTHR46033; PTHR46033; 1.
DR Pfam; PF10536; PMD; 1.
PE 1: Evidence at protein level;
KW Aminotransferase; Developmental protein; Growth regulation; Nucleus;
KW Reference proteome; Transferase.
FT CHAIN 1..478
FT /note="Protein MAINTENANCE OF MERISTEMS"
FT /id="PRO_0000438662"
FT REGION 459..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 464..468
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000269|PubMed:23607329"
FT MUTAGEN 465..467
FT /note="RKR->LNQ: Targets to the cytoplasm."
FT /evidence="ECO:0000269|PubMed:23607329"
SQ SEQUENCE 478 AA; 54697 MW; E413CD629B61823F CRC64;
MPVLYEQDKH VSSAILTGQE RGVLRCQERT SLLHHWKLTK EQIALVEKAG FGWFRLVGSI
SLNNSLISAL VERWRRETNT FHFPCGEMTI TLDEVSLILG LAVDGKPVVG VKEKDEDPSQ
VCLRLLGKLP KGELSGNRVT AKWLKESFAE CPKGATMKEI EYHTRAYLIY IVGSTIFATT
DPSKISVDYL ILFEDFEKAG EYAWGAAALA FLYRQIGNAS QRSQSIIGGC LTLLQCWSYF
HLNIDRPKRT TRQFPLALLW KGRQQSRSKN DLFKYRKALD DLDPSNVSWC PFEGDLDIVP
QSFKDNLLLG RSRTKLIGPK VVEWHFPDRC MKQFGLCQVI PGEVPPRKNE KNHDEDLLED
MNTADEEWMR RRENIVENGG GNGDESEYMQ WFNSITVPKL HRDTSLEADI MNVQAAILQF
DEVASTLSLE DLHPEEREAI EEAVMSMSNA LRVGDWYEAS TTNKRKRREE QQQTDWSE
