ID   MAIP1_BOVIN             Reviewed;         291 AA.
AC   A3KN05;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=m-AAA protease-interacting protein 1, mitochondrial {ECO:0000250|UniProtKB:Q8WWC4};
DE   AltName: Full=Matrix AAA peptidase-interacting protein 1 {ECO:0000250|UniProtKB:Q8WWC4};
DE   Flags: Precursor;
GN   Name=MAIP1 {ECO:0000250|UniProtKB:Q8WWC4};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring
CC       its maturation. Interacts with the transit peptide region of SMDT1/EMRE
CC       precursor protein in the mitochondrial matrix, leading to protect it
CC       against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE
CC       maturation by the mitochondrial processing peptidase (PMPCA and PMPCB).
CC       {ECO:0000250|UniProtKB:Q8WWC4}.
CC   -!- SUBUNIT: Interacts with AFG3L2. Interacts with SPG7. Interacts with
CC       SMDT1/EMRE (via the N-terminal transit peptide); interaction is direct
CC       and takes place before maturation of SMDT1/EMRE.
CC       {ECO:0000250|UniProtKB:Q8WWC4}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q8WWC4}.
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DR   EMBL; BC133463; AAI33464.1; -; mRNA.
DR   RefSeq; NP_001076875.1; NM_001083406.2.
DR   AlphaFoldDB; A3KN05; -.
DR   STRING; 9913.ENSBTAP00000025606; -.
DR   PaxDb; A3KN05; -.
DR   Ensembl; ENSBTAT00000025606; ENSBTAP00000025606; ENSBTAG00000019231.
DR   GeneID; 510566; -.
DR   KEGG; bta:510566; -.
DR   CTD; 79568; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019231; -.
DR   VGNC; VGNC:31150; MAIP1.
DR   eggNOG; ENOG502QR8E; Eukaryota.
DR   GeneTree; ENSGT00390000004145; -.
DR   HOGENOM; CLU_083348_0_0_1; -.
DR   InParanoid; A3KN05; -.
DR   OMA; TAIYEFQ; -.
DR   OrthoDB; 1056493at2759; -.
DR   TreeFam; TF323801; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000019231; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; ISS:UniProtKB.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central.
DR   GO; GO:0051204; P:protein insertion into mitochondrial membrane; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..96
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           97..291
FT                   /note="m-AAA protease-interacting protein 1, mitochondrial"
FT                   /id="PRO_0000301944"
SQ   SEQUENCE   291 AA;  32940 MW;  6397DD289F9DDE0F CRC64;
     MALAVRLLPR LLLSRPLPGW AARLRTLSSA EVKRPLSGLC YLCRRRLGSG AAPFPRVSWA
     SAALALSARG PQRPLLSPLE VASTLPTFPS CPRRTYSTEE QPQQRQKTKM IILGFSNPIN
     WVRTRIYSFL IWAYFDQEFS ITEFSEGAKQ AFAHVSKLLS QCKFDLLEEL VAKETLHVLK
     EKVTSLPDNH KNALAADIDE IVYTSTGDIS IYYDEKGRKF VNILMCFWYL TSANIPSEAI
     SGARVFQVKL GDQNVETKQL LSASYEFQRE FTQGVKPDWT IARIEHPKLL E