MAIP1_MOUSE
ID MAIP1_MOUSE Reviewed; 291 AA.
AC Q8BHE8; Q8R3N9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=m-AAA protease-interacting protein 1, mitochondrial {ECO:0000303|PubMed:27642048};
DE AltName: Full=Matrix AAA peptidase-interacting protein 1 {ECO:0000312|MGI:MGI:1915365};
DE Flags: Precursor;
GN Name=Maip1 {ECO:0000303|PubMed:27642048, ECO:0000312|MGI:MGI:1915365};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP INTERACTION WITH AFG3L2.
RX PubMed=27642048; DOI=10.1016/j.molcel.2016.08.020;
RA Koenig T., Troeder S.E., Bakka K., Korwitz A., Richter-Dennerlein R.,
RA Lampe P.A., Patron M., Muehlmeister M., Guerrero-Castillo S., Brandt U.,
RA Decker T., Lauria I., Paggio A., Rizzuto R., Rugarli E.I., De Stefani D.,
RA Langer T.;
RT "The m-AAA protease associated with neurodegeneration limits MCU activity
RT in mitochondria.";
RL Mol. Cell 64:148-162(2016).
CC -!- FUNCTION: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring
CC its maturation. Interacts with the transit peptide region of SMDT1/EMRE
CC precursor protein in the mitochondrial matrix, leading to protect it
CC against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE
CC maturation by the mitochondrial processing peptidase (PMPCA and PMPCB).
CC {ECO:0000250|UniProtKB:Q8WWC4}.
CC -!- SUBUNIT: Interacts with AFG3L2 (PubMed:27642048). Interacts with SPG7
CC (By similarity). Interacts with SMDT1/EMRE (via the N-terminal transit
CC peptide); interaction is direct and takes place before maturation of
CC SMDT1/EMRE (By similarity). {ECO:0000250|UniProtKB:Q8WWC4,
CC ECO:0000269|PubMed:27642048}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:Q8WWC4}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH24945.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK048123; BAC33250.1; -; mRNA.
DR EMBL; AK079116; BAC37547.1; -; mRNA.
DR EMBL; BC024945; AAH24945.1; ALT_INIT; mRNA.
DR EMBL; BC071241; AAH71241.1; -; mRNA.
DR CCDS; CCDS48266.1; -.
DR RefSeq; NP_001074650.1; NM_001081181.2.
DR AlphaFoldDB; Q8BHE8; -.
DR BioGRID; 212663; 2.
DR STRING; 10090.ENSMUSP00000027114; -.
DR iPTMnet; Q8BHE8; -.
DR PhosphoSitePlus; Q8BHE8; -.
DR SwissPalm; Q8BHE8; -.
DR EPD; Q8BHE8; -.
DR jPOST; Q8BHE8; -.
DR MaxQB; Q8BHE8; -.
DR PaxDb; Q8BHE8; -.
DR PeptideAtlas; Q8BHE8; -.
DR PRIDE; Q8BHE8; -.
DR ProteomicsDB; 292003; -.
DR Antibodypedia; 34082; 116 antibodies from 20 providers.
DR Ensembl; ENSMUST00000027114; ENSMUSP00000027114; ENSMUSG00000025971.
DR GeneID; 68115; -.
DR KEGG; mmu:68115; -.
DR UCSC; uc007bbc.2; mouse.
DR CTD; 79568; -.
DR MGI; MGI:1915365; Maip1.
DR VEuPathDB; HostDB:ENSMUSG00000025971; -.
DR eggNOG; ENOG502QR8E; Eukaryota.
DR GeneTree; ENSGT00390000004145; -.
DR HOGENOM; CLU_083348_0_0_1; -.
DR InParanoid; Q8BHE8; -.
DR OMA; TAIYEFQ; -.
DR OrthoDB; 1056493at2759; -.
DR PhylomeDB; Q8BHE8; -.
DR TreeFam; TF323801; -.
DR Reactome; R-MMU-8949664; Processing of SMDT1.
DR BioGRID-ORCS; 68115; 4 hits in 70 CRISPR screens.
DR ChiTaRS; Maip1; mouse.
DR PRO; PR:Q8BHE8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8BHE8; protein.
DR Bgee; ENSMUSG00000025971; Expressed in floor plate of midbrain and 257 other tissues.
DR Genevisible; Q8BHE8; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0036444; P:calcium import into the mitochondrion; ISS:UniProtKB.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central.
DR GO; GO:0051204; P:protein insertion into mitochondrial membrane; ISS:UniProtKB.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..96
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 97..291
FT /note="m-AAA protease-interacting protein 1, mitochondrial"
FT /id="PRO_0000301946"
SQ SEQUENCE 291 AA; 32985 MW; 26BF74A7978439A8 CRC64;
MALAARLLPL PLLSRPLPGP VTRLRTLGST EVRLTLTEIC CLCRRRLGSS AAPIPRYTRA
WTSPALRSWS SRRSLLGRVE HPPALASLPA SPSRSYSTEE QPQQRQRTRM IILGFSNPIN
WVRTRIYAFL IWAYFDKEFS IAEFSEGAKQ AFAYVSKLLS QCKFDLLEEL VAKEVLQILK
EKVTSLSDNH KNALAADIDD IVYTSTGDIS IYYDEKGRKF VNILMCFWYL TSANIPSESL
SGANVFQVKL GDQSVETKQL LSASYEFQRE FTQGVKPDWT IARIEHSKLL E
