MAIP1_RAT
ID MAIP1_RAT Reviewed; 291 AA.
AC Q6AY04;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=m-AAA protease-interacting protein 1, mitochondrial {ECO:0000250|UniProtKB:Q8WWC4};
DE AltName: Full=Matrix AAA peptidase-interacting protein 1 {ECO:0000312|RGD:1303159};
DE Flags: Precursor;
GN Name=Maip1 {ECO:0000312|RGD:1303159};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring
CC its maturation. Interacts with the transit peptide region of SMDT1/EMRE
CC precursor protein in the mitochondrial matrix, leading to protect it
CC against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE
CC maturation by the mitochondrial processing peptidase (PMPCA and PMPCB).
CC {ECO:0000250|UniProtKB:Q8WWC4}.
CC -!- SUBUNIT: Interacts with AFG3L2. Interacts with SPG7. Interacts with
CC SMDT1/EMRE (via the N-terminal transit peptide); interaction is direct
CC and takes place before maturation of SMDT1/EMRE.
CC {ECO:0000250|UniProtKB:Q8WWC4}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:Q8WWC4}.
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DR EMBL; BC079246; AAH79246.1; -; mRNA.
DR RefSeq; NP_001004251.1; NM_001004251.1.
DR AlphaFoldDB; Q6AY04; -.
DR STRING; 10116.ENSRNOP00000021533; -.
DR iPTMnet; Q6AY04; -.
DR PhosphoSitePlus; Q6AY04; -.
DR jPOST; Q6AY04; -.
DR PaxDb; Q6AY04; -.
DR PRIDE; Q6AY04; -.
DR Ensembl; ENSRNOT00000021533; ENSRNOP00000021533; ENSRNOG00000015983.
DR GeneID; 301418; -.
DR KEGG; rno:301418; -.
DR UCSC; RGD:1303159; rat.
DR CTD; 79568; -.
DR RGD; 1303159; Maip1.
DR eggNOG; ENOG502QR8E; Eukaryota.
DR GeneTree; ENSGT00390000004145; -.
DR HOGENOM; CLU_083348_0_0_1; -.
DR InParanoid; Q6AY04; -.
DR OMA; TAIYEFQ; -.
DR OrthoDB; 1056493at2759; -.
DR PhylomeDB; Q6AY04; -.
DR Reactome; R-RNO-8949664; Processing of SMDT1.
DR PRO; PR:Q6AY04; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000015983; Expressed in quadriceps femoris and 19 other tissues.
DR Genevisible; Q6AY04; RN.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0036444; P:calcium import into the mitochondrion; ISS:UniProtKB.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central.
DR GO; GO:0051204; P:protein insertion into mitochondrial membrane; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..96
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 97..291
FT /note="m-AAA protease-interacting protein 1, mitochondrial"
FT /id="PRO_0000301947"
SQ SEQUENCE 291 AA; 33090 MW; 3F953FD4C7AB0023 CRC64;
MALAARLLPL PLLSWSLPGR ATRLRTLRTT EVKLTLNEFC CLCRRRLGSS AAPIPRCTWA
WASPTMRSWG PRRPLLGRAE HSPALASLPA SPIRSYSTEE QPQQRQRTRM IILGFSNPIN
WVRTRIYAFL IWAYFDKEFS IAEFSEGAKQ AFAYVSKLLS QCKFDLLEEL VAKEVLQVLK
EKVASLSDNH KNALAADIDD IVYTSTGDIS IYYDEKGRKF VNILMCFWYL TSANIPSESL
SGANVFQVKL GDQSVETKQL LSASYEFQRE FTQGVKPDWT IARIEHSKLL E