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MAIP1_RAT
ID   MAIP1_RAT               Reviewed;         291 AA.
AC   Q6AY04;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=m-AAA protease-interacting protein 1, mitochondrial {ECO:0000250|UniProtKB:Q8WWC4};
DE   AltName: Full=Matrix AAA peptidase-interacting protein 1 {ECO:0000312|RGD:1303159};
DE   Flags: Precursor;
GN   Name=Maip1 {ECO:0000312|RGD:1303159};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring
CC       its maturation. Interacts with the transit peptide region of SMDT1/EMRE
CC       precursor protein in the mitochondrial matrix, leading to protect it
CC       against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE
CC       maturation by the mitochondrial processing peptidase (PMPCA and PMPCB).
CC       {ECO:0000250|UniProtKB:Q8WWC4}.
CC   -!- SUBUNIT: Interacts with AFG3L2. Interacts with SPG7. Interacts with
CC       SMDT1/EMRE (via the N-terminal transit peptide); interaction is direct
CC       and takes place before maturation of SMDT1/EMRE.
CC       {ECO:0000250|UniProtKB:Q8WWC4}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q8WWC4}.
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DR   EMBL; BC079246; AAH79246.1; -; mRNA.
DR   RefSeq; NP_001004251.1; NM_001004251.1.
DR   AlphaFoldDB; Q6AY04; -.
DR   STRING; 10116.ENSRNOP00000021533; -.
DR   iPTMnet; Q6AY04; -.
DR   PhosphoSitePlus; Q6AY04; -.
DR   jPOST; Q6AY04; -.
DR   PaxDb; Q6AY04; -.
DR   PRIDE; Q6AY04; -.
DR   Ensembl; ENSRNOT00000021533; ENSRNOP00000021533; ENSRNOG00000015983.
DR   GeneID; 301418; -.
DR   KEGG; rno:301418; -.
DR   UCSC; RGD:1303159; rat.
DR   CTD; 79568; -.
DR   RGD; 1303159; Maip1.
DR   eggNOG; ENOG502QR8E; Eukaryota.
DR   GeneTree; ENSGT00390000004145; -.
DR   HOGENOM; CLU_083348_0_0_1; -.
DR   InParanoid; Q6AY04; -.
DR   OMA; TAIYEFQ; -.
DR   OrthoDB; 1056493at2759; -.
DR   PhylomeDB; Q6AY04; -.
DR   Reactome; R-RNO-8949664; Processing of SMDT1.
DR   PRO; PR:Q6AY04; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000015983; Expressed in quadriceps femoris and 19 other tissues.
DR   Genevisible; Q6AY04; RN.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; ISS:UniProtKB.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR   GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central.
DR   GO; GO:0051204; P:protein insertion into mitochondrial membrane; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..96
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           97..291
FT                   /note="m-AAA protease-interacting protein 1, mitochondrial"
FT                   /id="PRO_0000301947"
SQ   SEQUENCE   291 AA;  33090 MW;  3F953FD4C7AB0023 CRC64;
     MALAARLLPL PLLSWSLPGR ATRLRTLRTT EVKLTLNEFC CLCRRRLGSS AAPIPRCTWA
     WASPTMRSWG PRRPLLGRAE HSPALASLPA SPIRSYSTEE QPQQRQRTRM IILGFSNPIN
     WVRTRIYAFL IWAYFDKEFS IAEFSEGAKQ AFAYVSKLLS QCKFDLLEEL VAKEVLQVLK
     EKVASLSDNH KNALAADIDD IVYTSTGDIS IYYDEKGRKF VNILMCFWYL TSANIPSESL
     SGANVFQVKL GDQSVETKQL LSASYEFQRE FTQGVKPDWT IARIEHSKLL E
 
 
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