ID   MAJIN_RAT               Reviewed;         251 AA.
AC   Q6AYM7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Membrane-anchored junction protein {ECO:0000250|UniProtKB:Q9D992};
GN   Name=Majin {ECO:0000250|UniProtKB:Q9D992};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Meiosis-specific telomere-associated protein involved in
CC       meiotic telomere attachment to the nucleus inner membrane, a crucial
CC       step for homologous pairing and synapsis. Component of the MAJIN-TERB1-
CC       TERB2 complex, which promotes telomere cap exchange by mediating
CC       attachment of telomeric DNA to the inner nuclear membrane and
CC       replacement of the protective cap of telomeric chromosomes: in early
CC       meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA
CC       and the shelterin/telosome complex. During prophase, the complex
CC       matures and promotes release of the shelterin/telosome complex from
CC       telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to
CC       the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly
CC       for the stabilization of telomere attachment on the nucleus inner
CC       membrane. {ECO:0000250|UniProtKB:Q9D992}.
CC   -!- SUBUNIT: Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN,
CC       TERB1 and TERB2. {ECO:0000250|UniProtKB:Q9D992}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q9D992}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9D992}. Chromosome, telomere
CC       {ECO:0000250|UniProtKB:Q9D992}. Note=In leptotene spermatocytes,
CC       localizes to telomeres that localize to the nucleus inner membrane.
CC       {ECO:0000250|UniProtKB:Q9D992}.
CC   -!- SIMILARITY: Belongs to the MAJIN family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC078985; AAH78985.1; -; mRNA.
DR   RefSeq; NP_001019462.1; NM_001024291.1.
DR   AlphaFoldDB; Q6AYM7; -.
DR   SMR; Q6AYM7; -.
DR   STRING; 10116.ENSRNOP00000065294; -.
DR   PaxDb; Q6AYM7; -.
DR   Ensembl; ENSRNOT00000077274; ENSRNOP00000072946; ENSRNOG00000054336.
DR   GeneID; 499306; -.
DR   KEGG; rno:499306; -.
DR   UCSC; RGD:1563886; rat.
DR   CTD; 283129; -.
DR   RGD; 1563886; Majin.
DR   eggNOG; ENOG502S50S; Eukaryota.
DR   GeneTree; ENSGT00390000007971; -.
DR   HOGENOM; CLU_094252_1_0_1; -.
DR   InParanoid; Q6AYM7; -.
DR   OMA; HLKFKHE; -.
DR   OrthoDB; 1129208at2759; -.
DR   PhylomeDB; Q6AYM7; -.
DR   TreeFam; TF336863; -.
DR   PRO; PR:Q6AYM7; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000054336; Expressed in testis and 2 other tissues.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR   GO; GO:0005639; C:integral component of nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISS:UniProtKB.
DR   GO; GO:0070197; P:meiotic attachment of telomere to nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0045141; P:meiotic telomere clustering; ISS:UniProtKB.
DR   InterPro; IPR027816; MAJIN.
DR   PANTHER; PTHR35824; PTHR35824; 1.
DR   Pfam; PF15077; MAJIN; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Meiosis; Membrane; Nucleus; Reference proteome;
KW   Telomere; Transmembrane; Transmembrane helix.
FT   CHAIN           1..251
FT                   /note="Membrane-anchored junction protein"
FT                   /id="PRO_0000325834"
FT   TOPO_DOM        1..227
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        228..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..251
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000305"
FT   REGION          140..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..184
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   251 AA;  28646 MW;  CAA3B87C573C4C93 CRC64;
     MSLKPFTYPF PETRFLHAGT NVYKFKIRYG NSIRGEEIED KGVIIQELED SIRAVLANMD
     SLQPFVTEHF IVFPYKSKWE RVSHLKFKHG EIILTPYPFV FTLYIEMKCF AESLPSGKPT
     DDIPLELVLT AKEAEEATMR KRKLMEEPST PSRPGPHRAK METWSEASST KKALKEHKRS
     WGEDSQQDTP ASDSTAVTEQ DPMLGHSLPG LVVPPLEHSN PPPLKEPAAR GFLGFLSALF
     PFRYFFRKST Q