ID   MAK16_DANRE             Reviewed;         303 AA.
AC   Q6NYD4; Q8JGS7;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Protein MAK16 homolog;
DE   AltName: Full=MAK16-like protein;
DE   AltName: Full=Protein RBM13;
GN   Name=mak16; Synonyms=mak16l, rbm13;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in early embryonic development.
CC       {ECO:0000269|PubMed:12006978}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Embryos show various defects including CNS
CC       necrosis, a thin yolk sac extension and small head and eyes.
CC       {ECO:0000269|PubMed:12006978}.
CC   -!- SIMILARITY: Belongs to the MAK16 family. {ECO:0000305}.
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DR   EMBL; AY099519; AAM28207.1; -; mRNA.
DR   EMBL; BC066636; AAH66636.1; -; mRNA.
DR   AlphaFoldDB; Q6NYD4; -.
DR   SMR; Q6NYD4; -.
DR   STRING; 7955.ENSDARP00000098580; -.
DR   PaxDb; Q6NYD4; -.
DR   ZFIN; ZDB-GENE-020419-35; mak16.
DR   eggNOG; KOG3064; Eukaryota.
DR   InParanoid; Q6NYD4; -.
DR   PhylomeDB; Q6NYD4; -.
DR   PRO; PR:Q6NYD4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   InterPro; IPR029004; L28e/Mak16.
DR   InterPro; IPR006958; Mak16.
DR   Pfam; PF04874; Mak16; 1.
DR   Pfam; PF01778; Ribosomal_L28e; 1.
DR   PIRSF; PIRSF003352; MAK16; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Protein MAK16 homolog"
FT                   /id="PRO_0000203796"
FT   REGION          189..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..229
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..260
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        29
FT                   /note="C -> W (in Ref. 1; AAM28207)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   303 AA;  35864 MW;  A18B1CADD1B834D0 CRC64;
     MQHDDVIWDL IGNKSFCSYK VKTKTQQFCR NEYNITGLCN RSSCPLANSQ YATIREEKGQ
     CFLYMKVIER AAFPSRMWEK VKLDRNYAKA LEQIDENLIY WPRFIRHKCK QRLTKITQYL
     IRIRKLTLKR QRKLVPLSRK VERREKRREE KALIAAQLEN AIEKELLDRL KQGTYGDIYN
     FPINAFDKAM EKQDEESESE EEEEEEDEEE SGTREFIAED EFEESDLSDF EELNNLKDSS
     DEEVNDEEES SEESEEESEE EEVKSKAKSK GKAPLKGPSR KKRAYVEIEY EQETEPAQKS
     KAT