ID   MAK16_SCHMA             Reviewed;         259 AA.
AC   P46435; Q9NBV7;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Protein MAK16 homolog;
DE   AltName: Full=SmMAK16;
GN   Name=MAK16; Synonyms=GST-6;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], NUCLEOLAR LOCALIZATION, AND
RP   PHOSPHORYLATION.
RX   PubMed=10838225; DOI=10.1016/s0166-6851(00)00221-8;
RA   Milhon J.L., Albert T.J., Vande Waa E.A., O'Leary K.A., Jackson R.N.,
RA   Kessler M.A., Schuler L.A., Tracy J.W.;
RT   "SmMAK16, the Schistosoma mansoni homologue of MAK16 from yeast, targets
RT   protein transport to the nucleolus.";
RL   Mol. Biochem. Parasitol. 108:225-236(2000).
RN   [2]
RP   FUNCTION.
RX   PubMed=14599666; DOI=10.1016/j.molbiopara.2003.08.006;
RA   Capowski E.E., Tracy J.W.;
RT   "Ribosomal RNA processing and the role of SmMAK16 in ribosome biogenesis in
RT   Schistosoma mansoni.";
RL   Mol. Biochem. Parasitol. 132:67-74(2003).
CC   -!- FUNCTION: Involved in biogenesis of the 60S ribosomal subunit.
CC       {ECO:0000269|PubMed:14599666}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus.
CC   -!- SIMILARITY: Belongs to the MAK16 family. {ECO:0000305}.
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DR   EMBL; AF243514; AAF78225.1; -; Genomic_DNA.
DR   EMBL; L06180; AAA29887.2; -; mRNA.
DR   RefSeq; XP_018645625.1; XM_018791105.1.
DR   AlphaFoldDB; P46435; -.
DR   SMR; P46435; -.
DR   STRING; 6183.Smp_050360.1; -.
DR   EnsemblMetazoa; Smp_050360.1; Smp_050360.1; Smp_050360.
DR   GeneID; 8353295; -.
DR   KEGG; smm:Smp_050360.1; -.
DR   WBParaSite; Smp_050360.1; Smp_050360.1; Smp_050360.
DR   CTD; 8353295; -.
DR   eggNOG; KOG3064; Eukaryota.
DR   HOGENOM; CLU_050888_2_0_1; -.
DR   OMA; ERCHTPR; -.
DR   OrthoDB; 1394336at2759; -.
DR   PhylomeDB; P46435; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   ExpressionAtlas; P46435; baseline.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR029004; L28e/Mak16.
DR   InterPro; IPR006958; Mak16.
DR   Pfam; PF04874; Mak16; 1.
DR   Pfam; PF01778; Ribosomal_L28e; 1.
DR   PIRSF; PIRSF003352; MAK16; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..259
FT                   /note="Protein MAK16 homolog"
FT                   /id="PRO_0000203792"
FT   REGION          97..150
FT                   /note="Nucleolar localization/retention signal"
FT   REGION          195..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           245..251
FT                   /note="Nuclear localization signal"
FT   MOD_RES         199
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         231
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   259 AA;  31008 MW;  44EB0CAFE56E61F6 CRC64;
     MNNDDVIWHT INHSFCSFVV KTKTGRFCRN DDNVTGLCNR HSCPLANSQY ATIKERDGII
     YLFVKEPERI PYPGKQWERI KLRRNKDQAL KQIKEHLLYW DKWIISRVKQ RFFRTREYLK
     NMRRLALSRQ KKLEPINRTV EKRELRREAK ALRVARIERT VEQELLERLR ASTSSKEIYN
     IDQSAFEKAL EAEEINEESD EEYEEDEEEI VYTSGSDVED IEDIGVIDEE SEEEEAEHNL
     VLTNPKKKRK VTIHYEKDE