MAKR1_ARATH
ID MAKR1_ARATH Reviewed; 341 AA.
AC Q3E936;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Probable membrane-associated kinase regulator 1;
GN Name=MAKR1; OrderedLocusNames=At5g26230; ORFNames=F9D12.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, NOMENCLATURE, AND INTERACTION WITH BRI1.
RX PubMed=21289069; DOI=10.1101/gad.2001911;
RA Jaillais Y., Hothorn M., Belkhadir Y., Dabi T., Nimchuk Z.L.,
RA Meyerowitz E.M., Chory J.;
RT "Tyrosine phosphorylation controls brassinosteroid receptor activation by
RT triggering membrane release of its kinase inhibitor.";
RL Genes Dev. 25:232-237(2011).
CC -!- FUNCTION: May negatively regulate brassinosteroid signaling.
CC -!- SUBUNIT: A C-terminus-derived peptide binds BRI1 in vitro.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
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DR EMBL; AC005965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF077407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93539.1; -; Genomic_DNA.
DR RefSeq; NP_197995.1; NM_122524.3.
DR AlphaFoldDB; Q3E936; -.
DR STRING; 3702.AT5G26230.1; -.
DR PaxDb; Q3E936; -.
DR PRIDE; Q3E936; -.
DR EnsemblPlants; AT5G26230.1; AT5G26230.1; AT5G26230.
DR GeneID; 832692; -.
DR Gramene; AT5G26230.1; AT5G26230.1; AT5G26230.
DR KEGG; ath:AT5G26230; -.
DR Araport; AT5G26230; -.
DR TAIR; locus:2179719; AT5G26230.
DR eggNOG; ENOG502QVKJ; Eukaryota.
DR HOGENOM; CLU_765951_0_0_1; -.
DR InParanoid; Q3E936; -.
DR OMA; MYCGDTS; -.
DR OrthoDB; 1387980at2759; -.
DR PhylomeDB; Q3E936; -.
DR PRO; PR:Q3E936; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q3E936; baseline and differential.
DR Genevisible; Q3E936; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0009536; C:plastid; IDA:TAIR.
DR GO; GO:0019210; F:kinase inhibitor activity; IMP:TAIR.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0009741; P:response to brassinosteroid; IMP:TAIR.
DR InterPro; IPR039620; BKI1/MAKR1/3/4.
DR PANTHER; PTHR33312; PTHR33312; 2.
PE 1: Evidence at protein level;
KW Brassinosteroid signaling pathway; Cell membrane; Lipid metabolism;
KW Membrane; Reference proteome.
FT CHAIN 1..341
FT /note="Probable membrane-associated kinase regulator 1"
FT /id="PRO_0000410476"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 341 AA; 36106 MW; 7BE00AC70F928F15 CRC64;
MRRQPPRPRN SPPQSHSSPS SSSSEFEFNI SISPRKASSS LCPADELFYK GQLLPLQLSP
RLSLVRTLGS STSSSDYTSS SSSSVATSAA RDSTESNSST DSTASFPLLH PPPLDCCDSS
RPSSVTDDED FFFKPPKNKS SSGGFSLSRF SSVFKKDPKT NLHHHSSSSS TATTAAAPSS
VKRMSSTAKE VIRKYMKKVK PLYEKLSPKQ SSNIKTESSS SLKDSGNNIR GTTTVTTVTA
APTVVSSGGG LSISFSGNLM KYTKRGRCAA SCPSSMRSSP NHSGVLTRGG FPVHQGSCSS
SSSNNNSVSS SMEELQSAIQ GAIAHCKNSM LQKNLVSSLE I
