MAKR2_ARATH
ID MAKR2_ARATH Reviewed; 411 AA.
AC Q9SH58; Q8GYQ8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Probable membrane-associated kinase regulator 2;
GN Name=MAKR2; OrderedLocusNames=At1g64080; ORFNames=F22C12.16, F22C12_2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21289069; DOI=10.1101/gad.2001911;
RA Jaillais Y., Hothorn M., Belkhadir Y., Dabi T., Nimchuk Z.L.,
RA Meyerowitz E.M., Chory J.;
RT "Tyrosine phosphorylation controls brassinosteroid receptor activation by
RT triggering membrane release of its kinase inhibitor.";
RL Genes Dev. 25:232-237(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
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DR EMBL; AC007764; AAF24565.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34189.1; -; Genomic_DNA.
DR EMBL; AK117446; BAC42111.1; -; mRNA.
DR EMBL; BT025625; ABF59043.1; -; mRNA.
DR PIR; E96665; E96665.
DR RefSeq; NP_176591.1; NM_105081.4.
DR AlphaFoldDB; Q9SH58; -.
DR STRING; 3702.AT1G64080.1; -.
DR iPTMnet; Q9SH58; -.
DR PaxDb; Q9SH58; -.
DR PRIDE; Q9SH58; -.
DR ProteomicsDB; 238810; -.
DR EnsemblPlants; AT1G64080.1; AT1G64080.1; AT1G64080.
DR GeneID; 842712; -.
DR Gramene; AT1G64080.1; AT1G64080.1; AT1G64080.
DR KEGG; ath:AT1G64080; -.
DR Araport; AT1G64080; -.
DR TAIR; locus:2024573; AT1G64080.
DR eggNOG; ENOG502QRKI; Eukaryota.
DR HOGENOM; CLU_056837_0_0_1; -.
DR InParanoid; Q9SH58; -.
DR OMA; PVPAECN; -.
DR OrthoDB; 1462994at2759; -.
DR PhylomeDB; Q9SH58; -.
DR PRO; PR:Q9SH58; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SH58; baseline and differential.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR039619; MAKR2/5.
DR PANTHER; PTHR33929; PTHR33929; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome.
FT CHAIN 1..411
FT /note="Probable membrane-associated kinase regulator 2"
FT /id="PRO_0000410477"
FT REGION 184..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 75
FT /note="A -> T (in Ref. 3; BAC42111)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 411 AA; 44511 MW; DA4EFD73C5D7797D CRC64;
MEAFSLLNYW KNSGGAVTFL PHSSESSSSS LCRYSAGESI GTTTIVTSVT ETEDEEADEN
DDEGPFFDLE FALPAEEEDT DGGVGREGDS DCTDGGCEFK FTLSSCSGGE DRVDPDSLDD
VFFKETIVEE VEPPTSSEQQ TCSVKAPAAQ LSASILKTAT KLRVFMLGMK KSKLIQAKSE
ANFGSEDLDK QTHPPPPLSL SPESQQKSTV TVNLKVEEVP IISLFSRENS SKNSSSSSSS
SSSSSSSLKK QNGNESVVSD EKRFVMMQKY LKKVKPLYIR VSRRYGEKLR HSGQLTAPSS
ARSTAEKADS PVATKTNNKP GNNINIPAGL KVVRKHLGKS RSSSSTATTP SSTTATVTTQ
SESRRRDDSL LQQQDSIQSA ILHCKRSFNS SRDKDPSVLP RSVSEPSSYE K
