ID   MAKR4_ARATH             Reviewed;         328 AA.
AC   O80624;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Probable membrane-associated kinase regulator 4;
GN   Name=MAKR4; OrderedLocusNames=At2g39370; ORFNames=F12L6.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21289069; DOI=10.1101/gad.2001911;
RA   Jaillais Y., Hothorn M., Belkhadir Y., Dabi T., Nimchuk Z.L.,
RA   Meyerowitz E.M., Chory J.;
RT   "Tyrosine phosphorylation controls brassinosteroid receptor activation by
RT   triggering membrane release of its kinase inhibitor.";
RL   Genes Dev. 25:232-237(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
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DR   EMBL; AC004218; AAC27828.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09666.1; -; Genomic_DNA.
DR   PIR; T00547; T00547.
DR   RefSeq; NP_181469.1; NM_129494.2.
DR   AlphaFoldDB; O80624; -.
DR   STRING; 3702.AT2G39370.1; -.
DR   PaxDb; O80624; -.
DR   PRIDE; O80624; -.
DR   ProteomicsDB; 238627; -.
DR   EnsemblPlants; AT2G39370.1; AT2G39370.1; AT2G39370.
DR   GeneID; 818522; -.
DR   Gramene; AT2G39370.1; AT2G39370.1; AT2G39370.
DR   KEGG; ath:AT2G39370; -.
DR   Araport; AT2G39370; -.
DR   TAIR; locus:2039722; AT2G39370.
DR   eggNOG; ENOG502RCYF; Eukaryota.
DR   HOGENOM; CLU_048960_0_0_1; -.
DR   InParanoid; O80624; -.
DR   OMA; RKLRFMR; -.
DR   OrthoDB; 1117885at2759; -.
DR   PhylomeDB; O80624; -.
DR   PRO; PR:O80624; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O80624; baseline and differential.
DR   Genevisible; O80624; AT.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0019210; F:kinase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR039620; BKI1/MAKR1/3/4.
DR   PANTHER; PTHR33312; PTHR33312; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..328
FT                   /note="Probable membrane-associated kinase regulator 4"
FT                   /id="PRO_0000410479"
FT   REGION          213..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   328 AA;  37139 MW;  E258DA27FA7F0F3C CRC64;
     MAAYLERCDS VEEDYIDMEV TSFTNLVRKT LSNNYPREFE FQMSHLCPLE IDKTTSPADE
     LFYKGKLLPL HLPPRLQMVQ KILEDYTFDD EFYSTPLATG TVTTPVTSNT PFESCTVSPA
     ESCQVSKELN PEDYFLEYSD SLEEDDEKKK SWTTKLRLMK QSSLGTKIKA SRAYLRSFFG
     KTSCSDESSC ASSAARVADE DSVLRYSRVK PFGQIKTERP KKQSNGSVSG SHRRSFSVSM
     RRQAAKSSNN KSSNSLGFRP LQFLKRSTSS SSEIENSIQG AILHCKQSQQ QKQKQKQYST
     VNEVGFCSLS ASRIAARDDQ EWAQMFRG