ID   MAK_MYCA1               Reviewed;         452 AA.
AC   A0QN14;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Maltokinase;
DE            Short=MaK;
DE            EC=2.7.1.175;
DE   AltName: Full=Maltose-1-phosphate synthase;
GN   Name=mak; OrderedLocusNames=MAV_5185;
OS   Mycobacterium avium (strain 104).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=243243;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of maltose to
CC       maltose 1-phosphate. Is involved in a branched alpha-glucan
CC       biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB
CC       (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+);
CC         Xref=Rhea:RHEA:31915, ChEBI:CHEBI:15378, ChEBI:CHEBI:17306,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63576, ChEBI:CHEBI:456216;
CC         EC=2.7.1.175;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000479; ABK69468.1; -; Genomic_DNA.
DR   RefSeq; WP_011726512.1; NC_008595.1.
DR   AlphaFoldDB; A0QN14; -.
DR   SMR; A0QN14; -.
DR   EnsemblBacteria; ABK69468; ABK69468; MAV_5185.
DR   KEGG; mav:MAV_5185; -.
DR   HOGENOM; CLU_029675_0_0_11; -.
DR   OMA; TAFCDGY; -.
DR   OrthoDB; 268166at2; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001574; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046835; P:carbohydrate phosphorylation; ISS:UniProtKB.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0005992; P:trehalose biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR040999; Mak_N_cap.
DR   Pfam; PF18085; Mak_N_cap; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Glycogen biosynthesis;
KW   Glycogen metabolism; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN           1..452
FT                   /note="Maltokinase"
FT                   /id="PRO_0000412882"
SQ   SEQUENCE   452 AA;  49143 MW;  CFA7BB0A965B38CF CRC64;
     MTEPAKLPWS DWLPQQRWYA GRNRRLTGAE PSVIVGLRDD LDLVLVDADY ADGSRDRYQV
     LVCWDAAPVS EYSTVATIGA ADDRTGFDAL YDDEAPQFLL SLIDSSAVRS ASGAEVRFAK
     EPDAQLPLEA MAHVSDAEQS NTSVIFDRDA IFKVFRRVSS GINPDIELNR VLGRAGNPHV
     ARLLGTYEMA GADGTPETAW PLGMVTEFAA NAAEGWAMAT ASVRDLFAEG DLYAHEVGGD
     FAGESYRLGE AVASVHATLA ETLGTSQAAF PVDNVLARLS STAALVPELT EYAATIEERF
     AKLATETITV QRVHGDLHLG QVLRTPESWL LIDFEGEPGQ PLEERRAPDS PLRDVAGVLR
     SFEYAAYGPL VEQGSQNTDK QLAARAREWV ERNRTAFCDG YAAASGIDPR DSAPLLAAYE
     LDKAVYEAGY EARHRPGWLP IPLRSIARLT AA