ID   MAL12_MALDO             Reviewed;         159 AA.
AC   Q40280; O22517;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Major allergen Mal d 1;
DE   AltName: Full=AP15;
DE   AltName: Full=Allergen Mal d I;
DE   AltName: Allergen=Mal d 1;
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Golden Delicious; TISSUE=Pericarp;
RA   Atkinson R.G., Perry J., Matsui T., Ross G.S., MacRae E.A.;
RT   "A stress-, pathogenesis-, and allergen-related cDNA in apple fruit is also
RT   ripening-related.";
RL   N. Z. J. Crop Hortic. Sci. 24:103-107(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Idared;
RA   Son D.Y., Haustein D., Vieths S.;
RT   "Cloning and characterization of isoforms of the major apple allergen, Mal
RT   d 1, derived from different apple strains.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. McIntosh 'Wijcik'; TISSUE=Leaf;
RA   Puehringer H., Watillon B., Laimer da Camara Machado M.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the BetVI family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42952; AAB01362.1; -; mRNA.
DR   EMBL; AF074721; AAC26136.1; -; mRNA.
DR   EMBL; AF020542; AAD13683.1; -; Genomic_DNA.
DR   RefSeq; NP_001281292.1; NM_001294363.1.
DR   AlphaFoldDB; Q40280; -.
DR   SMR; Q40280; -.
DR   STRING; 3750.XP_008361947.1; -.
DR   Allergome; 1456; Mal d 1.0201.
DR   Allergome; 1461; Mal d 1.0206.
DR   Allergome; 464; Mal d 1.
DR   EnsemblPlants; mRNA:MD16G0142600; mRNA:MD16G0142600; MD16G0142600.
DR   GeneID; 103425638; -.
DR   Gramene; mRNA:MD16G0142600; mRNA:MD16G0142600; MD16G0142600.
DR   KEGG; mdm:103425638; -.
DR   OrthoDB; 1381244at2759; -.
DR   GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR000916; Bet_v_I/MLP.
DR   InterPro; IPR024949; Bet_v_I_allergen.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF00407; Bet_v_1; 1.
DR   PRINTS; PR00634; BETALLERGEN.
DR   PROSITE; PS00451; PATHOGENESIS_BETVI; 1.
PE   1: Evidence at protein level;
KW   Allergen; Pathogenesis-related protein; Plant defense.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..159
FT                   /note="Major allergen Mal d 1"
FT                   /id="PRO_0000154191"
FT   VARIANT         22
FT                   /note="A -> G"
SQ   SEQUENCE   159 AA;  17539 MW;  7332100D2C614446 CRC64;
     MGVYTFENEY TSEIPPPRLF KAFVLDADNL IPKIAPQAIK HAEILEGDGG PGTIKKITFG
     EGSQYGYVKH KIDSVDEANY SYAYTLIEGD ALTDTIEKVS YETKLVASGS GSIIKSISHY
     HTKGDVEIKE EHVKAGKEKA HGLFKLIESY LKGHPDAYN