MAL13_YEAST
ID MAL13_YEAST Reviewed; 473 AA.
AC P53338; D6VV65;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Maltose fermentation regulatory protein MAL13;
GN Name=MAL13; Synonyms=MAL1R; OrderedLocusNames=YGR288W; ORFNames=G9591;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9090054;
RX DOI=10.1002/(sici)1097-0061(19970315)13:3<251::aid-yea63>3.0.co;2-r;
RA Volckaert G., Voet M., Robben J.;
RT "Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right
RT arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus
RT reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2
RT genes and an ABC transporter gene.";
RL Yeast 13:251-259(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Regulates the coordinate transcription of structural MAL1S
CC (maltase) and AGT1 (maltose permease) genes.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the MAL13 family. {ECO:0000305}.
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DR EMBL; Z73073; CAA97320.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08376.1; -; Genomic_DNA.
DR PIR; S64623; S64623.
DR RefSeq; NP_011804.1; NM_001181417.1.
DR AlphaFoldDB; P53338; -.
DR BioGRID; 33538; 42.
DR IntAct; P53338; 1.
DR MINT; P53338; -.
DR STRING; 4932.YGR288W; -.
DR MaxQB; P53338; -.
DR PaxDb; P53338; -.
DR PRIDE; P53338; -.
DR EnsemblFungi; YGR288W_mRNA; YGR288W; YGR288W.
DR GeneID; 853205; -.
DR KEGG; sce:YGR288W; -.
DR SGD; S000003520; MAL13.
DR VEuPathDB; FungiDB:YGR288W; -.
DR eggNOG; ENOG502S2FW; Eukaryota.
DR GeneTree; ENSGT00940000176316; -.
DR HOGENOM; CLU_046324_0_0_1; -.
DR InParanoid; P53338; -.
DR OMA; WPVIDHE; -.
DR BioCyc; YEAST:G3O-30948-MON; -.
DR PRO; PR:P53338; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53338; protein.
DR GO; GO:0005634; C:nucleus; ISS:SGD.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0044262; P:cellular carbohydrate metabolic process; IMP:SGD.
DR GO; GO:0000023; P:maltose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:SGD.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR020448; Maltose_ferment_reg_DNA-bd.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR PRINTS; PR00054; FUNGALZNCYS.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Maltose metabolism; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..473
FT /note="Maltose fermentation regulatory protein MAL13"
FT /id="PRO_0000114956"
FT DNA_BIND 13..39
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT MOTIF 46..54
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 473 AA; 54325 MW; 24471B42CCC9F782 CRC64;
MTLTKQTCAK QACDCCRIRR VKCDGKRPCS SCLQNSLDCT YLQPSRKRGP KSIRLRSLKR
IAEVQRESGP NTIATAPVIY KRVPKKLIDQ CLRLYHDNLY VIWPLLSYDD LHKLLEEKYN
DNYVYWFLTA LSAATLSDLQ TEIKSEEEVT FTGKQLSNLC ISSCQQFDDL DNSNIFNIMT
YYCLHRSFAQ ISNARTSYRL CCEAVGLITV AGLHREETYG SLTFEEQQLR RKLYYLLLMT
ERYYAIYLHC ATSLDATIAP PQLELVTDPQ LSMDSFLEMI RVFTVPGKCF FDALAADSTD
ASCTEESLKK IWNELHTTSS EIEPWSNGYI DISFSRHWIR ILAWKLAYQM RGSNFSLNAN
NGQIPIEIAR DMLIDTYLTP ENLYDVHGPG VPVKTLEIAT ALVDIVGQYD HNMKLEAWNV
LHDVCKFAFS LNHYNNDMLK RFSTKCQNAL ITLPISKPLQ LDGYPKDNED IDP
