ID   MAL2_BOVIN              Reviewed;         176 AA.
AC   A2VE13;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Protein MAL2;
GN   Name=MAL2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the machinery of polarized transport. Required for
CC       the indirect transcytotic route at the step of the egress of the
CC       transcytosing cargo from perinuclear endosomes in order for it to
CC       travel to the apical surface via a raft-dependent pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TPD52L2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Apical cell membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Note=Associated with lipid rafts. In
CC       polarized epithelial cells, restricted to the apical surface (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR   EMBL; BC133516; AAI33517.1; -; mRNA.
DR   RefSeq; NP_001075188.1; NM_001081719.1.
DR   AlphaFoldDB; A2VE13; -.
DR   STRING; 9913.ENSBTAP00000015638; -.
DR   PaxDb; A2VE13; -.
DR   PRIDE; A2VE13; -.
DR   Ensembl; ENSBTAT00000015638; ENSBTAP00000015638; ENSBTAG00000011779.
DR   GeneID; 511940; -.
DR   KEGG; bta:511940; -.
DR   CTD; 114569; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011779; -.
DR   VGNC; VGNC:54901; MAL2.
DR   eggNOG; KOG4788; Eukaryota.
DR   GeneTree; ENSGT00940000159514; -.
DR   HOGENOM; CLU_112950_2_0_1; -.
DR   InParanoid; A2VE13; -.
DR   OMA; FAYHFVV; -.
DR   OrthoDB; 1387690at2759; -.
DR   TreeFam; TF316174; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000011779; Expressed in rumen papilla and 97 other tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR   GO; GO:0042552; P:myelination; IBA:GO_Central.
DR   GO; GO:0045056; P:transcytosis; IEA:InterPro.
DR   InterPro; IPR013295; MAL.
DR   InterPro; IPR033240; MAL2.
DR   InterPro; IPR008253; Marvel.
DR   PANTHER; PTHR22776:SF42; PTHR22776:SF42; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR01884; MALPROTEIN.
DR   PROSITE; PS51225; MARVEL; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..176
FT                   /note="Protein MAL2"
FT                   /id="PRO_0000332209"
FT   TOPO_DOM        1..34
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..66
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..149
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..176
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          31..175
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
SQ   SEQUENCE   176 AA;  19146 MW;  CB554F1BB27E997C CRC64;
     MSAGGAPVPP PPNPAMSFPA PRVTLPAGPD ILRTYSGAFV CLEIVFGGLV WILVASSNVP
     LPLLQGWVMF VSVTAFVCSL LFLGVFLSGV VTQINANWNF LDFAYHFTVF VFYFGAFLLE
     AATTSLHDLR CNRTMTVQPL LSDNQYNINV AATIFAFVTT ACYGCSLGLA LRRWRP