MAL2_PONAB
ID MAL2_PONAB Reviewed; 176 AA.
AC Q5RAI2;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Protein MAL2;
GN Name=MAL2;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Member of the machinery of polarized transport. Required for
CC the indirect transcytotic route at the step of the egress of the
CC transcytosing cargo from perinuclear endosomes in order for it to
CC travel to the apical surface via a raft-dependent pathway (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TPD52L2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Apical cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Associated with lipid rafts. In
CC polarized epithelial cells, restricted to the apical surface (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR EMBL; CR859033; CAH91228.1; -; mRNA.
DR RefSeq; NP_001127390.1; NM_001133918.1.
DR AlphaFoldDB; Q5RAI2; -.
DR STRING; 9601.ENSPPYP00000021138; -.
DR GeneID; 100174457; -.
DR KEGG; pon:100174457; -.
DR CTD; 114569; -.
DR eggNOG; KOG4788; Eukaryota.
DR InParanoid; Q5RAI2; -.
DR OrthoDB; 1387690at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045121; C:membrane raft; IEA:InterPro.
DR GO; GO:0045056; P:transcytosis; IEA:InterPro.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR033240; MAL2.
DR InterPro; IPR008253; Marvel.
DR PANTHER; PTHR22776:SF42; PTHR22776:SF42; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..176
FT /note="Protein MAL2"
FT /id="PRO_0000156810"
FT TOPO_DOM 1..34
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..66
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..149
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..175
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 19257 MW; 5DB605A5BCC2E6CD CRC64;
MSAGGASVPP PPNPAVSFPV PRVTLPAGPD ILRTYSGAFV CLEILFGGLV WILVASSNVP
LPLLQGWVMF VSVTAFFFSL LFLGLFLSGM VTQIDANWNF LDFAYHFTVF VFYFGAFLLE
AAATSLHDLH YNITMTGQPL LNDNQYNINV AASIFAFMTT ACYGCSLGLA LRRWRP
