ID   MAL33_YEAST             Reviewed;         468 AA.
AC   P38157; D6VQU2;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Maltose fermentation regulatory protein MAL33;
GN   Name=MAL33; Synonyms=MAL3R; OrderedLocusNames=YBR297W; ORFNames=YBR2115;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- FUNCTION: Regulates the coordinate transcription of structural MAL3S
CC       (maltase) and MAL3T (maltose permease) genes.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the MAL13 family. {ECO:0000305}.
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DR   EMBL; Z36166; CAA85262.1; -; Genomic_DNA.
DR   EMBL; AY692789; AAT92808.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07412.1; -; Genomic_DNA.
DR   PIR; S46179; S46179.
DR   RefSeq; NP_009856.3; NM_001178645.3.
DR   AlphaFoldDB; P38157; -.
DR   BioGRID; 32990; 192.
DR   STRING; 4932.YBR297W; -.
DR   MaxQB; P38157; -.
DR   PaxDb; P38157; -.
DR   PRIDE; P38157; -.
DR   EnsemblFungi; YBR297W_mRNA; YBR297W; YBR297W.
DR   GeneID; 852600; -.
DR   KEGG; sce:YBR297W; -.
DR   SGD; S000000501; MAL33.
DR   VEuPathDB; FungiDB:YBR297W; -.
DR   eggNOG; ENOG502S2FW; Eukaryota.
DR   GeneTree; ENSGT00940000176316; -.
DR   HOGENOM; CLU_046324_0_0_1; -.
DR   InParanoid; P38157; -.
DR   OMA; NSAMMFI; -.
DR   BioCyc; YEAST:G3O-29215-MON; -.
DR   PRO; PR:P38157; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38157; protein.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000023; P:maltose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR020448; Maltose_ferment_reg_DNA-bd.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   PRINTS; PR00054; FUNGALZNCYS.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Maltose metabolism; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..468
FT                   /note="Maltose fermentation regulatory protein MAL33"
FT                   /id="PRO_0000114957"
FT   DNA_BIND        8..34
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   MOTIF           41..49
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   468 AA;  54194 MW;  EA8674EFEC56E5E9 CRC64;
     MTLVKYACDY CRVRRVKCDG KKPCSRCIEH NFDCTYQQPL KKRGSKPIGT RSLKYIPKAK
     MFIDNKSCTA AAEILMKVPK KVIDQCLRLY HDNLYVIWPL LSYDDLHKLL DEEYNDHYVY
     WFLVALSAAN LSDLQSELES EGGFSFTGKQ LAVLCMSSRQ QFDDLSGRDI FRIMTYYCLL
     RCFSQSSDVR NSYRLCREAI GLVIVAGLHR EKAYESLSFR EQQLLRKVYY LLLLTERYYS
     VYVHCVTSLD TTIAPPQPEF VTDPRLSLDS FFEMIRVFTV PGKCFFDALA TESTSGSCTE
     DSLKKIWKEL HTASLEIEPW SYGYVDISFS RHWIRALAWK LVFQMNGTKF FSNANNAHIL
     VEIAKDMLDD IFLTPNNLYD VHGPGIPMKS LEVANALVDI VNKYDHNMKL EAWNILCDVS
     KFVFSLKHCN HKMFQRFSTK CQSALIDLPI SRPLRLNDDS KDEDDIIP