MAL61_YEASX
ID MAL61_YEASX Reviewed; 614 AA.
AC P15685;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Maltose permease MAL61;
DE AltName: Full=Maltose transport protein MAL61;
GN Name=MAL61; Synonyms=MAL6T;
OS Saccharomyces cerevisiae (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=4932;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Carlsbergensis / JM1901;
RX PubMed=2507395; DOI=10.1016/0378-1119(89)90201-1;
RA Yao B., Sollitti P., Marmur J.;
RT "Primary structure of the maltose-permease-encoding gene of Saccharomyces
RT carlsbergensis.";
RL Gene 79:189-197(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2689282; DOI=10.1093/genetics/123.3.477;
RA Cheng Q., Michels C.A.;
RT "The maltose permease encoded by the MAL61 gene of Saccharomyces cerevisiae
RT exhibits both sequence and structural homology to other sugar
RT transporters.";
RL Genetics 123:477-484(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-31.
RC STRAIN=Carlsbergensis / CB11;
RX PubMed=3516795; DOI=10.1016/0378-1119(86)90269-6;
RA Hong S.H., Marmur J.;
RT "Primary structure of the maltase gene of the MAL6 locus of Saccharomyces
RT carlsbergensis.";
RL Gene 41:75-84(1986).
CC -!- FUNCTION: Transporter for maltose.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; M27823; AAA34758.1; -; Genomic_DNA.
DR EMBL; X17391; CAA35254.1; -; Genomic_DNA.
DR EMBL; M12601; AAA34756.2; -; Genomic_DNA.
DR PIR; S07686; MMBY61.
DR AlphaFoldDB; P15685; -.
DR SMR; P15685; -.
DR TCDB; 2.A.1.1.10; the major facilitator superfamily (mfs).
DR PRIDE; P15685; -.
DR SGD; S000029658; MAL61.
DR VEuPathDB; FungiDB:YBR298C; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0000023; P:maltose metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Maltose metabolism; Membrane; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..614
FT /note="Maltose permease MAL61"
FT /id="PRO_0000050423"
FT TOPO_DOM 1..108
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..144
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..180
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..460
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 482..493
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 515..526
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 548..614
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 68226 MW; 68985650466608B5 CRC64;
MKGLSSLINR KKDRNDSHLD EIENGVNATE FNSIEMEEQG KKSDFDLSHL EYGPGSLIPN
DNNEEVPDLL DEAMQDAKEA DESERGMPLM TALKTYPKAA AWSLLVSTTL IQEGYDTAIL
GAFYALPVFQ KKYGSLNSNT GDYEISVSWQ IGLCLCYMAG EIVGLQVTGP SVDYMGNRYT
LIMALFFLAA FIFILYFCKS LGMIAVGQAL CGMPWGCFQC LTVSYASEIC PLALRYYLTT
YSNLCWTFGQ LFAAGIMKNS QNKYANSELG YKLPFALQWI WPLPLAVGIF LAPESPWWLV
KKGRIDQARR SLERILSGKG PEKELLVSME LDKIKTTIEK EQKMSDEGTY WDCVKDGINR
RRTRIACLCW IGQCSCGASL IGYSTYFYEK AGVSTDTAFT FSIIQYCLGI AATFVSWWAS
KYCGRFDLYA FGLAFQAIMF FIIGGLGCSD THGAKMGSGA LLMVVAFFYN LGIAPVVFCL
VSEMPSSRLR TKTIILARNA YNVIQVVVTV LIMYQLNSEK WNWGAKSGFF WGGFCLATLA
WAVVDLPETA GRTFIEINEL FRLGVPARKF KSTKVDPFAA AKAAAAEINV KDPKEDLETS
VVDEGRSTPS VVNK
