ID   MAL63_YEASX             Reviewed;         473 AA.
AC   P10508;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Maltose fermentation regulatory protein MAL63;
GN   Name=MAL63; Synonyms=MAL6R;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Carlsbergensis / JM1901;
RX   PubMed=2851710; DOI=10.1007/bf00333398;
RA   Sollitti P., Marmur J.;
RT   "Primary structure of the regulatory gene from the MAL6 locus of
RT   Saccharomyces carlsbergensis.";
RL   Mol. Gen. Genet. 213:56-62(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3145816; DOI=10.1007/bf00419988;
RA   Kim J., Michels C.A.;
RT   "The MAL63 gene of Saccharomyces encodes a cysteine-zinc finger protein.";
RL   Curr. Genet. 14:319-323(1988).
CC   -!- FUNCTION: Regulates the coordinate transcription of structural MAL6S
CC       (maltase) and MAL6T (maltose permease) genes.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the MAL13 family. {ECO:0000305}.
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DR   EMBL; X12576; CAA31088.1; -; Genomic_DNA.
DR   EMBL; M36537; AAA34755.1; -; Genomic_DNA.
DR   PIR; S03814; RGBYM3.
DR   AlphaFoldDB; P10508; -.
DR   SGD; S000029659; MAL63.
DR   VEuPathDB; FungiDB:YPR196W; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000023; P:maltose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:SGD.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR020448; Maltose_ferment_reg_DNA-bd.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   PRINTS; PR00054; FUNGALZNCYS.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Maltose metabolism; Metal-binding; Nucleus;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..473
FT                   /note="Maltose fermentation regulatory protein MAL63"
FT                   /id="PRO_0000114958"
FT   DNA_BIND        8..34
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   MOTIF           41..49
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        90..91
FT                   /note="Missing (in Ref. 2; AAA34755)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        206
FT                   /note="Missing (in Ref. 2; AAA34755)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   473 AA;  54896 MW;  679111C8871E643D CRC64;
     MGIAKQSCDC CRVRRVKCDR NKPCNRCIQR NLNCTYLQPL KKRGPKSIRA GSLKKIAEVQ
     MVSMNNNIMA APVVCKKVPK NLIDQCLRLR LYHDNLYVIW PMLSYDDLHK LLEEKYDDRC
     AYWFLVSLSA ATLSDLQIEI EYEEGVTFTG EQLCTLCMLS RQFFDDLSNS DIFRIMTYYC
     LHRCYAQFAD TRTSYRLSCE AVGLIIKIAG FHREETYEFL PFGEQQLRRK VYYLLLMTER
     FYAVYIKCVT SLDATIAPPL PEVVTDPRLS LESFLEVIRV FTIPGKCFYD ALATNCVDDS
     CTEDSLKRIR NELHTTSLDI EPWSYGYIDF LFSRHWVRTL AWKLVLHMKG MRMNFLSNTN
     NTHIPVEIAR DMLGDTFLTP KNLYDVHGPG IPMKALEIAN ALVDVVNKYD HNMKLEAWNV
     LYDVSKFVFS LKHCNNKMFD RFSTKCQGAL ITLPISKPLQ LNDNSKDEDD IIP