ID   MALA_GEOSE              Reviewed;         394 AA.
AC   Q45632;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Maltose permease;
GN   Name=malA;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 7953 / DSM 5934 / JCM 9488 / NBRC 13737 / NCIB 8157 / NCTC
RC   10007 / NCA 1518;
RX   PubMed=8190087; DOI=10.1007/bf00301070;
RA   Liong E.C., Ferenci T.;
RT   "Molecular cloning of a maltose transport gene from Bacillus
RT   stearothermophilus and its expression in Escherichia coli K-12.";
RL   Mol. Gen. Genet. 243:343-352(1994).
CC   -!- FUNCTION: High affinity transport of maltose.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; L13418; AAA71980.1; -; Unassigned_DNA.
DR   PIR; S43915; S43915.
DR   AlphaFoldDB; Q45632; -.
DR   SMR; Q45632; -.
DR   TCDB; 2.A.1.65.9; the major facilitator superfamily (mfs).
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR024989; MFS_assoc_dom.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF12832; MFS_1_like; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..394
FT                   /note="Maltose permease"
FT                   /id="PRO_0000196191"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        12..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        39..45
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        46..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        75..78
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        79..104
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        105..108
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        109..126
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        127..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        138..160
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        161..163
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        164..183
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        184..213
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        214..233
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        234..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        238..262
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        263..272
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        293..295
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        296..318
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        319..330
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        331..358
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        359..361
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        362..382
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        383..394
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   394 AA;  42326 MW;  298D69429D059793 CRC64;
     MGAAFKWGAA ARKTVFPLFY FLIFFAFGAL FPLLSVYLQE EARLSGAAIG WIMSLPPIVT
     MAAQPLWGTA ADYTRKPVGL LLAALVLAAL FGVMYALAGS YRLFVVLTVL LSAMQSAIVP
     LSDSLALRHV HEQGGNYGAI RLWGSLGFAM AVLAVGWLSD HIAFAVIFYA FSLALLTAAA
     LATRLPRYPM GAPGALTRQD VRGLLASRPF RLLLVATFLL FGPILANNSY FGLLIHELGG
     TLTGIGLAFL FAAGSEAPFM KAADRLIGRF GMVRLLLLAA LISAARWLAY AADPPLWFVY
     MTTVVQGCSV GLAIPTALQY ARRLAPERVQ STAVALYSAV GNGLGAWFCT LVGGYLLERW
     QIGAVYLFFS ICTIVGVLVL LLLAKRERTA GEEK