MALC_STRPN
ID MALC_STRPN Reviewed; 435 AA.
AC P0A4N1; Q04698;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Maltodextrin transport system permease protein MalC;
GN Name=malC; OrderedLocusNames=SP_2109;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8478935; DOI=10.1006/jmbi.1993.1202;
RA Puyet A., Espinosa M.;
RT "Structure of the maltodextrin-uptake locus of Streptococcus pneumoniae.
RT Correlation to the Escherichia coli maltose regulon.";
RL J. Mol. Biol. 230:800-811(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC maltodextrin; probably responsible for the translocation of the
CC substrate across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. MalFG subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA26926.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L08611; AAA26926.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE005672; AAK76168.1; -; Genomic_DNA.
DR PIR; G95246; G95246.
DR RefSeq; WP_001808667.1; NZ_AKVY01000001.1.
DR AlphaFoldDB; P0A4N1; -.
DR SMR; P0A4N1; -.
DR STRING; 170187.SP_2109; -.
DR EnsemblBacteria; AAK76168; AAK76168; SP_2109.
DR KEGG; spn:SP_2109; -.
DR eggNOG; COG1175; Bacteria.
DR OMA; WYAYAMI; -.
DR PhylomeDB; P0A4N1; -.
DR BioCyc; SPNE170187:G1FZB-2197-MON; -.
DR BRENDA; 2.4.1.25; 1960.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR030156; MalF-like.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR47314:SF1; PTHR47314:SF1; 2.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..435
FT /note="Maltodextrin transport system permease protein MalC"
FT /id="PRO_0000060094"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 195..423
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT CONFLICT 236..239
FT /note="LLPW -> PSSL (in Ref. 1; AAA26926)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="D -> E (in Ref. 1; AAA26926)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 435 AA; 48302 MW; 32259E3E44AFC4DF CRC64;
MKGVNMEKQQ PSKAALLSII PGLGQIYNKQ KAKGFIFLGV TIVFVLYFLA LATPELSNLI
TLGDKPGRDN SLFMLIRGAF HLIFVIVYVL FYFSNIKDAH TIAKRINNGI PVPRTLKDMI
KGIYENGFPY LLIIPSYVAM TFAIIFPVIV TLMIAFTNYD FQHLPPNKLL DWVGLTNFTN
IWSLSTFRSA FGSVLSWTII WALAASTLQI VIGIFTAIIA NQPFIKGKRI FGVIFLLPWA
VPAFITILTF SNMFNDSVGA INTQVLPILA KFLPFLDGAL IPWKTDPTWT KIALIMMQGW
LGFPYIYVLT LGILQSIPND LYEAAYIDGA NAWQKFRNIT FPMILAVAAP TLISQYTFNF
NNFSIMYLFN GGGPGSVGGG AGSTDILISW IYRLTTGTSP QYSMAAAVTL IISIIVISIS
MIAFKKLHAF DMEDV
