ID   MALD1_DANRE             Reviewed;         162 AA.
AC   Q5BLB7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=MARVEL domain-containing protein 1;
GN   Name=marveld1; ORFNames=im:7136220;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Nucleus {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH90512.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC090512; AAH90512.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001189346.1; NM_001202417.1.
DR   AlphaFoldDB; Q5BLB7; -.
DR   STRING; 7955.ENSDARP00000011783; -.
DR   PaxDb; Q5BLB7; -.
DR   Ensembl; ENSDART00000019379; ENSDARP00000011783; ENSDARG00000011724.
DR   GeneID; 497317; -.
DR   KEGG; dre:497317; -.
DR   CTD; 83742; -.
DR   ZFIN; ZDB-GENE-050208-33; marveld1.
DR   eggNOG; KOG4788; Eukaryota.
DR   GeneTree; ENSGT00510000049375; -.
DR   HOGENOM; CLU_138621_0_0_1; -.
DR   InParanoid; Q5BLB7; -.
DR   OMA; RWLCTNL; -.
DR   OrthoDB; 1449334at2759; -.
DR   PhylomeDB; Q5BLB7; -.
DR   TreeFam; TF316174; -.
DR   PRO; PR:Q5BLB7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000011724; Expressed in swim bladder and 25 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR   GO; GO:0042552; P:myelination; IBA:GO_Central.
DR   InterPro; IPR013295; MAL.
DR   InterPro; IPR008253; Marvel.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR01884; MALPROTEIN.
DR   PROSITE; PS51225; MARVEL; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..162
FT                   /note="MARVEL domain-containing protein 1"
FT                   /id="PRO_0000271524"
FT   TOPO_DOM        1..17
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..127
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          14..155
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ   SEQUENCE   162 AA;  18354 MW;  B7674DE37A040E62 CRC64;
     MPTQPQEKRS FLQFLKSFVG IVRVLQILLG AGLWVTIAAN KYEGSIHFVL FVAVLFWLLT
     LAIFILTLLD KQDLVPIVGG ERWLLSNLIH DVVATLLYLS TIGIMIYKTQ KNSYCNLDVY
     KHHCLYKVYL TASVFACLTA AVYLLSGIYC SCRKCRGERT VV