MALD1_MOUSE
ID MALD1_MOUSE Reviewed; 173 AA.
AC Q7TQJ1; Q8BHQ3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=MARVEL domain-containing protein 1;
GN Name=Marveld1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum, and Embryoid bodies;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21347699; DOI=10.1007/s10059-011-0037-3;
RA Zeng F., Tian Y., Shi S., Wu Q., Liu S., Zheng H., Yue L., Li Y.;
RT "Identification of mouse MARVELD1 as a microtubule associated protein that
RT inhibits cell cycle progression and migration.";
RL Mol. Cells 31:267-274(2011).
CC -!- FUNCTION: Microtubule-associated protein that exhibits cell cycle-
CC dependent localization and can inhibit cell proliferation and
CC migration. {ECO:0000269|PubMed:21347699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21347699};
CC Multi-pass membrane protein {ECO:0000269|PubMed:21347699}. Nucleus
CC {ECO:0000269|PubMed:21347699}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:21347699}. Note=Observed in the nucleus and at the
CC perinuclear region during interphase, but localizes at the mitotic
CC spindle and midbody at metaphase. A significant fraction of MARVELD1
CC translocates to the plasma membrane during anaphase or upon microtubule
CC depolymerization.
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DR EMBL; AK081212; BAC38165.1; -; mRNA.
DR EMBL; AK132243; BAE21054.1; -; mRNA.
DR EMBL; BC054384; AAH54384.1; -; mRNA.
DR CCDS; CCDS50439.1; -.
DR RefSeq; NP_899018.1; NM_183195.2.
DR AlphaFoldDB; Q7TQJ1; -.
DR STRING; 10090.ENSMUSP00000053733; -.
DR PhosphoSitePlus; Q7TQJ1; -.
DR MaxQB; Q7TQJ1; -.
DR PaxDb; Q7TQJ1; -.
DR PeptideAtlas; Q7TQJ1; -.
DR PRIDE; Q7TQJ1; -.
DR ProteomicsDB; 292008; -.
DR Antibodypedia; 56528; 74 antibodies from 19 providers.
DR DNASU; 277010; -.
DR Ensembl; ENSMUST00000061111; ENSMUSP00000053733; ENSMUSG00000044345.
DR GeneID; 277010; -.
DR KEGG; mmu:277010; -.
DR UCSC; uc008hni.2; mouse.
DR CTD; 83742; -.
DR MGI; MGI:2147570; Marveld1.
DR VEuPathDB; HostDB:ENSMUSG00000044345; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00510000049375; -.
DR InParanoid; Q7TQJ1; -.
DR OMA; RWLCTNL; -.
DR OrthoDB; 1449334at2759; -.
DR PhylomeDB; Q7TQJ1; -.
DR TreeFam; TF316174; -.
DR BioGRID-ORCS; 277010; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Marveld1; mouse.
DR PRO; PR:Q7TQJ1; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q7TQJ1; protein.
DR Bgee; ENSMUSG00000044345; Expressed in ascending aorta and 236 other tissues.
DR ExpressionAtlas; Q7TQJ1; baseline and differential.
DR Genevisible; Q7TQJ1; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0042552; P:myelination; IBA:GO_Central.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell cycle; Cell membrane; Cytoplasm; Cytoskeleton; Membrane;
KW Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..173
FT /note="MARVEL domain-containing protein 1"
FT /id="PRO_0000271523"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..166
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9BSK0"
FT CONFLICT 20
FT /note="L -> W (in Ref. 1; BAC38165)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 173 AA; 19087 MW; 7BA77E5316ED4BE2 CRC64;
MLPPPPRQPP PQARTARGSL RLQRAFLRGP LGVLRLLQLL AGAAFWITIA TSKYQGPVHF
ALFVSVLFWL LTLGLYFITL LGKQELVPVL GSRWLVVNVA HDLLAAALYG AATGIMIDQT
QRHSYCNLKN YRLPCAYHAF LAASVCGGLC LGLYLLSALY GCCRRYQGKE EVV
