ID   MALD_STRPN              Reviewed;         280 AA.
AC   P0A4N3; Q04699;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Maltodextrin transport system permease protein MalD;
GN   Name=malD; OrderedLocusNames=SP_2110;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8478935; DOI=10.1006/jmbi.1993.1202;
RA   Puyet A., Espinosa M.;
RT   "Structure of the maltodextrin-uptake locus of Streptococcus pneumoniae.
RT   Correlation to the Escherichia coli maltose regulon.";
RL   J. Mol. Biol. 230:800-811(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       maltodextrin; probably responsible for the translocation of the
CC       substrate across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. MalFG subfamily. {ECO:0000305}.
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DR   EMBL; L08611; AAA26927.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK76169.1; -; Genomic_DNA.
DR   PIR; H95246; H95246.
DR   PIR; S32571; S32571.
DR   RefSeq; WP_001065636.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0A4N3; -.
DR   SMR; P0A4N3; -.
DR   STRING; 170187.SP_2110; -.
DR   EnsemblBacteria; AAK76169; AAK76169; SP_2110.
DR   GeneID; 60233531; -.
DR   GeneID; 66807189; -.
DR   KEGG; spn:SP_2110; -.
DR   eggNOG; COG3833; Bacteria.
DR   OMA; NTYLMYG; -.
DR   PhylomeDB; P0A4N3; -.
DR   BioCyc; SPNE170187:G1FZB-2198-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..280
FT                   /note="Maltodextrin transport system permease protein MalD"
FT                   /id="PRO_0000060096"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          73..265
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   CONFLICT        1..8
FT                   /note="MNNSIKLK -> MILITQ (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        15..16
FT                   /note="LT -> Y (in Ref. 1; AAA26927)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        63..74
FT                   /note="LFTETLYGTWYL -> PSLKPCTVLGTF (in Ref. 1; AAA26927)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   280 AA;  31508 MW;  B99FE845BF728C87 CRC64;
     MNNSIKLKRR LTQSLTYLYL IGLSIVIIYP LLITIMSAFK AGNVSAFKLD TNIDLNFDNF
     KGLFTETLYG TWYLNTLIIA LITMAVQTSI IVLAGYAYSR YNFLARKQSL VFFLIIQMVP
     TMAALTAFFV MALMLNALNH NWFLIFLYVG GGIPMNAWLM KGYFDTVPMS LDESAKLDGA
     GHFRRFWQIV LPLVRPMVAV QALWAFMGPF GDYILSSFLL REKEYFTVAV GLQTFVNNAK
     NLKIAYFSAG AILIALPICI LFFFLQKNFV SGLTSGGDKG