MALE_SALTY
ID MALE_SALTY Reviewed; 396 AA.
AC P19576;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Maltose/maltodextrin-binding periplasmic protein {ECO:0000250|UniProtKB:P0AEX9};
DE AltName: Full=MMBP {ECO:0000250|UniProtKB:P0AEX9};
DE AltName: Full=Maltodextrin-binding protein {ECO:0000250|UniProtKB:P0AEX9};
DE AltName: Full=Maltose-binding protein {ECO:0000250|UniProtKB:P0AEX9};
DE Short=MBP {ECO:0000250|UniProtKB:P0AEX9};
DE Flags: Precursor;
GN Name=malE; OrderedLocusNames=STM4229;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=2674653; DOI=10.1007/bf00331269;
RA Dahl M.K., Francoz E., Saurin W., Boos W., Manson M.D., Hofnung M.;
RT "Comparison of sequences from the malB regions of Salmonella typhimurium
RT and Enterobacter aerogenes with Escherichia coli K12: a potential new
RT regulatory site in the interoperonic region.";
RL Mol. Gen. Genet. 218:199-207(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=1730061; DOI=10.1016/0167-4781(92)90492-i;
RA Schneider E., Francoz E., Dassa E.;
RT "Completion of the nucleotide sequence of the 'maltose B' region in
RT Salmonella typhimurium: the high conservation of the malM gene suggests a
RT selected physiological role for its product.";
RL Biochim. Biophys. Acta 1129:223-227(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC maltose/maltodextrin import. Binds maltose and higher maltodextrins.
CC {ECO:0000250|UniProtKB:P0AEX9}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC two transmembrane proteins (MalG and MalF) and a solute-binding protein
CC (MalE). {ECO:0000250|UniProtKB:P0AEX9}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:P0AEX9}.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL23053.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X54292; CAA38189.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL23053.1; ALT_INIT; Genomic_DNA.
DR PIR; S05331; S05331.
DR RefSeq; NP_463094.3; NC_003197.2.
DR PDB; 3JYR; X-ray; 1.75 A; A=1-396.
DR PDB; 6L0Z; X-ray; 1.60 A; A=27-396.
DR PDB; 6L3E; X-ray; 1.60 A; A=27-396.
DR PDBsum; 3JYR; -.
DR PDBsum; 6L0Z; -.
DR PDBsum; 6L3E; -.
DR AlphaFoldDB; P19576; -.
DR SMR; P19576; -.
DR IntAct; P19576; 2.
DR STRING; 99287.STM4229; -.
DR PaxDb; P19576; -.
DR EnsemblBacteria; AAL23053; AAL23053; STM4229.
DR GeneID; 1255755; -.
DR KEGG; stm:STM4229; -.
DR PATRIC; fig|99287.12.peg.4449; -.
DR HOGENOM; CLU_031285_17_0_6; -.
DR OMA; WAHDWIG; -.
DR PhylomeDB; P19576; -.
DR EvolutionaryTrace; P19576; -.
DR PRO; PR:P19576; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IBA:GO_Central.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1901982; F:maltose binding; IBA:GO_Central.
DR GO; GO:0042956; P:maltodextrin transmembrane transport; IBA:GO_Central.
DR GO; GO:0015768; P:maltose transport; IBA:GO_Central.
DR InterPro; IPR006060; Maltose/Cyclodextrin-bd.
DR InterPro; IPR006059; SBP.
DR InterPro; IPR006061; SBP_1_CS.
DR Pfam; PF01547; SBP_bac_1; 1.
DR PRINTS; PR00181; MALTOSEBP.
DR PROSITE; PS01037; SBP_BACTERIAL_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Periplasm; Reference proteome; Signal; Sugar transport;
KW Transport.
FT SIGNAL 1..26
FT CHAIN 27..396
FT /note="Maltose/maltodextrin-binding periplasmic protein"
FT /id="PRO_0000031697"
FT CONFLICT 128..129
FT /note="KL -> NV (in Ref. 1; CAA38189 and 2)"
FT /evidence="ECO:0000305"
FT STRAND 32..36
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 43..57
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 61..64
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 69..77
FT /evidence="ECO:0007829|PDB:6L0Z"
FT TURN 78..80
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 84..89
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 90..92
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 93..98
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 109..112
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 117..122
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 131..137
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 140..144
FT /evidence="ECO:0007829|PDB:6L0Z"
FT TURN 145..147
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 153..155
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 158..167
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 171..173
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:3JYR"
FT HELIX 180..189
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 193..197
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 202..211
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 212..226
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 236..244
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 247..253
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 255..257
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 258..263
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 268..271
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 284..293
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 299..308
FT /evidence="ECO:0007829|PDB:6L0Z"
FT TURN 309..311
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 313..322
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 327..330
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 331..337
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 341..352
FT /evidence="ECO:0007829|PDB:6L0Z"
FT STRAND 353..355
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 362..377
FT /evidence="ECO:0007829|PDB:6L0Z"
FT HELIX 383..394
FT /evidence="ECO:0007829|PDB:6L0Z"
SQ SEQUENCE 396 AA; 43181 MW; 2D76BAD17BC502A9 CRC64;
MKIKTGVGIL ALSALTTMMI SAPALAKIEE GKLVIWINGD KGYNGLAEVG KKFEQDTGIK
VTVEHPDKLE EKFPQVAATG DGPDIIFWAH DRFGGYAQSG LLAEVTPDKA FQDKLYPFTW
DAVRYNGKLI AYPIAVEALS LIYNKDLVPN PPKTWEEIPA LDKELKVKGK SAIMFNLQEP
YFTWPLIAAD GGYAFKFENG KYDVKDVGVD NAGAKAGLTF LIDMIKNKNM SADTDYSIAE
AAFNKGETAM TINGPWAWSN IDKSKVNYGV TLLPTFKGKP SKPFVGVLSA GINAASPNKE
LAKEFLENYL LTDQGLEAVN KDKPLGAVAL KSFQEQLAKD PRIAATMDNA QKGEIMPNIP
QMSAFWYAVR TAVINAASGR QTVDAALKDA QSRITK
