ID   MALF_SHIFL              Reviewed;         514 AA.
AC   Q83P81;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2003, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Maltose/maltodextrin transport system permease protein MalF {ECO:0000250|UniProtKB:P02916};
GN   Name=malF; OrderedLocusNames=SF4172, S3559;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC       maltose/maltodextrin import. Probably responsible for the translocation
CC       of the substrate across the membrane. {ECO:0000250|UniProtKB:P02916}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC       two transmembrane proteins (MalG and MalF) and a solute-binding protein
CC       (MalE). {ECO:0000250|UniProtKB:P02916}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P02916}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P02916}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. MalFG subfamily. {ECO:0000305}.
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DR   EMBL; AE005674; AAN45593.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18606.1; -; Genomic_DNA.
DR   RefSeq; NP_709886.2; NC_004337.2.
DR   AlphaFoldDB; Q83P81; -.
DR   BMRB; Q83P81; -.
DR   SMR; Q83P81; -.
DR   STRING; 198214.SF4172; -.
DR   EnsemblBacteria; AAN45593; AAN45593; SF4172.
DR   EnsemblBacteria; AAP18606; AAP18606; S3559.
DR   GeneID; 1023460; -.
DR   KEGG; sfl:SF4172; -.
DR   KEGG; sfx:S3559; -.
DR   PATRIC; fig|198214.7.peg.4922; -.
DR   HOGENOM; CLU_016047_20_0_6; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   Gene3D; 1.20.58.370; -; 1.
DR   InterPro; IPR030156; MalF-like.
DR   InterPro; IPR035277; MalF_N.
DR   InterPro; IPR029345; MalF_P2.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   PANTHER; PTHR47314:SF1; PTHR47314:SF1; 1.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF14785; MalF_P2; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..514
FT                   /note="Maltose/maltodextrin transport system permease
FT                   protein MalF"
FT                   /id="PRO_0000060075"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        35..37
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        59..70
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        92..276
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        298..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        341..371
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        393..416
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        438..483
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        484..504
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        505..514
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          281..505
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   CONFLICT        410
FT                   /note="L -> P (in Ref. 2; AAP18606)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   514 AA;  57029 MW;  939D5CC2EB789DA7 CRC64;
     MDVIKKKHWW QSDALKWSVL GLLGLLVGYL VVLMYAQGEY LFAITTLILS SAGLYIFANR
     KAYAWRYVYP GMAGMGLFVL FPLVCTIAIA FTNYSSTNQL TFERAQEVLL DRSWQAGKTY
     NFGLYPAGDE WQLALSDGET GKNYLSDAFK FGGEQKLQLK ETTAQPEGER ANLRVITQNR
     QALSDITAIL PDGNKVMMSS LRQFSGTQPL YTLDGDGTLT NNQSGVKYRP NNQIGFYQSI
     TADGNWGDEK LSPGYTVTTG WKNFTRVFTD EGIQKPFLAI FVWTVVFSLI TVFLTVAVGM
     VLACLVQWEA LRGKAVYRVL LILPYAVPSF ISILIFKGLF NQSFGEINMM LSALFGVKPA
     WFSDPTTART MLIIVNTWLG YPYMMILCMG LLKAIPDDLY EASAMDGAGL FQNFFKITLP
     LLIKPLTPLM IASFAFNFNN FVLIQLLTNG GPDRLGTTTP AGYTDLLVNY TYRIAFEGGG
     GQDFGLAAAI ATLIFLLVGA LAIVNLKATR MKFD