MALF_THELN
ID MALF_THELN Reviewed; 295 AA.
AC O51924; H3ZP66; Q9HH26;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Trehalose/maltose transport system permease protein MalF;
GN Name=malF; ORFNames=OCC_03557;
OS Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=523849;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C;
RX PubMed=9457875; DOI=10.1128/jb.180.3.680-689.1998;
RA Horlacher R., Xavier K.B., Santos H., DiRuggiero J., Kossmann M., Boos W.;
RT "Archaeal binding protein-dependent ABC transporter: molecular and
RT biochemical analysis of the trehalose/maltose transport system of the
RT hyperthermophilic archaeon Thermococcus litoralis.";
RL J. Bacteriol. 180:680-689(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C;
RX PubMed=11115105; DOI=10.1046/j.1365-2958.2000.02161.x;
RA Diruggiero J., Dunn D., Maeder D.L., Holley-Shanks R., Chatard J.,
RA Horlacher R., Robb F.T., Boos W., Weiss R.B.;
RT "Evidence of recent lateral gene transfer among hyperthermophilic
RT archaea.";
RL Mol. Microbiol. 38:684-693(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C;
RX PubMed=22493191; DOI=10.1128/jb.00123-12;
RA Gardner A.F., Kumar S., Perler F.B.;
RT "Genome sequence of the model hyperthermophilic archaeon Thermococcus
RT litoralis NS-C.";
RL J. Bacteriol. 194:2375-2376(2012).
RN [4]
RP FUNCTION.
RC STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C;
RX PubMed=8759837; DOI=10.1128/jb.178.16.4773-4777.1996;
RA Xavier K.B., Martins L.O., Peist R., Kossmann M., Boos W., Santos H.;
RT "High-affinity maltose/trehalose transport system in the hyperthermophilic
RT archaeon Thermococcus litoralis.";
RL J. Bacteriol. 178:4773-4777(1996).
RN [5]
RP FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX PubMed=11453995; DOI=10.1046/j.1432-1327.2001.02313.x;
RA Greller G., Riek R., Boos W.;
RT "Purification and characterization of the heterologously expressed
RT trehalose/maltose ABC transporter complex of the hyperthermophilic archaeon
RT Thermococcus litoralis.";
RL Eur. J. Biochem. 268:4011-4018(2001).
RN [6]
RP CRYSTALLIZATION, AND SUBUNIT.
RX PubMed=12454482; DOI=10.1107/s090744490201572x;
RA Schiefner A., Diederichs K., Hashimoto K., Boos W., Welte W.;
RT "Crystallization and preliminary X-ray analysis of the trehalose/maltose
RT ABC transporter MalFGK2 from Thermococcus litoralis.";
RL Acta Crystallogr. D 58:2147-2149(2002).
CC -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC trehalose/maltose import. Responsible for the translocation of the
CC substrate across the membrane. {ECO:0000269|PubMed:11453995,
CC ECO:0000269|PubMed:8759837}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC two transmembrane proteins (MalG and MalF) and a solute-binding protein
CC (MalE). {ECO:0000269|PubMed:11453995, ECO:0000269|PubMed:12454482}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11453995};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441,
CC ECO:0000269|PubMed:11453995}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC38137.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF012836; AAC38137.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF307053; AAG45389.1; -; Genomic_DNA.
DR EMBL; CP006670; EHR78233.1; -; Genomic_DNA.
DR PIR; T46751; T46751.
DR RefSeq; WP_004068722.1; NC_022084.1.
DR AlphaFoldDB; O51924; -.
DR SMR; O51924; -.
DR STRING; 523849.OCC_03557; -.
DR TCDB; 3.A.1.1.7; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; EHR78233; EHR78233; OCC_03557.
DR GeneID; 16548948; -.
DR KEGG; tlt:OCC_03557; -.
DR HOGENOM; CLU_016047_0_3_2; -.
DR OMA; LPMIRRS; -.
DR OrthoDB; 42250at2157; -.
DR Proteomes; UP000015502; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..295
FT /note="Trehalose/maltose transport system permease protein
FT MalF"
FT /id="PRO_0000421286"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 75..286
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT CONFLICT 176
FT /note="F -> L (in Ref. 1; AAC38137)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 33054 MW; 2BFA377C55075454 CRC64;
MDNNLTSKLK YREAKLGYLM ILPLLTVVLV FIILPVMGTF WISLHRDVTF IPEKPFVGLR
NYLRVLSARE FWYSTFVTVS FSFVSVSLET ILGLSFALIL NERLKGRGVL RAIVLIPWAV
PTIISARTWE LMYNYSYGLF NWILSILGVS PVNWLGTPIS AFFAIVIADV WKTTPFMTLL
LLAGLQAIPQ DLYEAALIDG ASMFERFKSI TLPLLKPVLI VALILRTIDA LRVFDIIYVL
TGGGPGGATT SISLLAFNYY NLGDYGIGSA ISILTFVLVL SFTIVYLKVG RFRRD
