MALF_YERPE
ID MALF_YERPE Reviewed; 530 AA.
AC Q74RF9; Q0WAU2; Q8D1U0; Q8ZAS5;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Maltose/maltodextrin transport system permease protein MalF {ECO:0000250|UniProtKB:P02916};
GN Name=malF; OrderedLocusNames=YPO3715, y0027, YP_3077;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC maltose/maltodextrin import. Probably responsible for the translocation
CC of the substrate across the membrane. {ECO:0000250|UniProtKB:P02916}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC two transmembrane proteins (MalG and MalF) and a solute-binding protein
CC (MalE). {ECO:0000250|UniProtKB:P02916}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P02916}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P02916}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. MalFG subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAL22302.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL22302.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE009952; AAM83622.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS63248.1; -; Genomic_DNA.
DR PIR; AC0452; AC0452.
DR RefSeq; YP_002348596.1; NC_003143.1.
DR AlphaFoldDB; Q74RF9; -.
DR SMR; Q74RF9; -.
DR STRING; 214092.YPO3715; -.
DR PaxDb; Q74RF9; -.
DR DNASU; 1144974; -.
DR EnsemblBacteria; AAM83622; AAM83622; y0027.
DR EnsemblBacteria; AAS63248; AAS63248; YP_3077.
DR KEGG; ype:YPO3715; -.
DR KEGG; ypk:y0027; -.
DR KEGG; ypm:YP_3077; -.
DR PATRIC; fig|214092.21.peg.4225; -.
DR eggNOG; COG1175; Bacteria.
DR HOGENOM; CLU_016047_20_0_6; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:1990060; C:maltose transport complex; IBA:GO_Central.
DR GO; GO:0015423; F:ABC-type maltose transporter activity; IBA:GO_Central.
DR GO; GO:0042956; P:maltodextrin transmembrane transport; IBA:GO_Central.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR Gene3D; 1.20.58.370; -; 1.
DR InterPro; IPR030156; MalF-like.
DR InterPro; IPR035277; MalF_N.
DR InterPro; IPR029345; MalF_P2.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR47314:SF1; PTHR47314:SF1; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR Pfam; PF14785; MalF_P2; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..530
FT /note="Maltose/maltodextrin transport system permease
FT protein MalF"
FT /id="PRO_0000060080"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..49
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 50..52
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..70
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 71..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..105
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 106..295
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 319..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..352
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 353..385
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..408
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 409..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 452..499
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..522
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 523..530
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 297..521
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 530 AA; 59092 MW; 94C9836C4A4FCA79 CRC64;
MKGNIMQLSH TELQSRKKKI AWWQSDALKW LVISLLSLFT CYLIVLMYAQ GEYLFAIVTL
ILVSLGLYVF ANRRAYAWRY VYPGVAGMGL FVLFPLICTI AIAFTNYSST NQLTFERAQS
VLLDRQFQTG KTFTFGLYPS DNQWRLQLTN PDDGSLFISE PFSFEATGEQ KVMVAPTNTA
QTSEPASLRI ITQSRQALSS LVAILPDGAE LRMSSLRQFS GTKPLYTLGA DGKELINQQT
GVKYWPNPST GFYQAVNADG QWENEKLSPG FTVSIGWKNF LRVLHDEGIQ KPFISIFIWT
ILFSVMSVTF TVAVGMVLAC VVQWDSLKGK AIYRVMLILP YAVPSFISIL IFKGLFNQSF
GEINLMLSHL FGIKPAWFSD PITAKSMILI VNTWLGYPYM MILCMGLLKA IPDDLYEASA
MDGAGPFQNF FRITFPLLIK PLTPLMIASF AFNFNNFVLI QLLTNGGPDM IGTSTPAGYT
DLLVNYTYRV AFEGEGGQDF GLAAAIATLI FILVGALAIL NLKASKMNFD
