MALK_ALIF1
ID MALK_ALIF1 Reviewed; 369 AA.
AC Q5DZC6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Maltose/maltodextrin import ATP-binding protein MalK {ECO:0000255|HAMAP-Rule:MF_01709};
DE EC=7.5.2.1 {ECO:0000255|HAMAP-Rule:MF_01709};
GN Name=malK {ECO:0000255|HAMAP-Rule:MF_01709}; OrderedLocusNames=VF_A0800;
OS Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Aliivibrio.
OX NCBI_TaxID=312309;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700601 / ES114;
RX PubMed=15703294; DOI=10.1073/pnas.0409900102;
RA Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R.,
RA Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E.,
RA Stevens A., Visick K., Whistler C., Greenberg E.P.;
RT "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with
RT pathogenic congeners.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005).
CC -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC maltose/maltodextrin import. Responsible for energy coupling to the
CC transport system. {ECO:0000255|HAMAP-Rule:MF_01709}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:22132, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17306, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.1;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01709};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC two transmembrane proteins (MalG and MalK) and a solute-binding protein
CC (MalE). {ECO:0000255|HAMAP-Rule:MF_01709}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01709}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01709}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC Maltooligosaccharide importer (TC 3.A.1.1.1) family.
CC {ECO:0000255|HAMAP-Rule:MF_01709}.
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DR EMBL; CP000021; AAW87870.1; -; Genomic_DNA.
DR RefSeq; WP_011263621.1; NC_006841.2.
DR RefSeq; YP_206758.1; NC_006841.2.
DR AlphaFoldDB; Q5DZC6; -.
DR SMR; Q5DZC6; -.
DR STRING; 312309.VF_A0800; -.
DR EnsemblBacteria; AAW87870; AAW87870; VF_A0800.
DR KEGG; vfi:VF_A0800; -.
DR PATRIC; fig|312309.11.peg.3402; -.
DR eggNOG; COG3842; Bacteria.
DR HOGENOM; CLU_000604_1_1_6; -.
DR OMA; SPKAFLM; -.
DR OrthoDB; 1200451at2; -.
DR Proteomes; UP000000537; Chromosome II.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0015423; F:ABC-type maltose transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03301; ABC_MalK_N; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015855; ABC_transpr_MalK-like.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR040582; OB_MalK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17912; OB_MalK; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; SSF50331; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51245; MALK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Sugar transport; Translocase;
KW Transport.
FT CHAIN 1..369
FT /note="Maltose/maltodextrin import ATP-binding protein
FT MalK"
FT /id="PRO_0000274001"
FT DOMAIN 4..234
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
SQ SEQUENCE 369 AA; 40833 MW; 033D3DD2DE25A6CA CRC64;
MTSVTLRNVC KSYGDVKISK NVDLDINSGE FVVFVGPSGC GKSTLLRCIA GLEDITSGDL
YMGDKRMNDV EPSKRGVGMV FQSYALYPHL NLFDNMSFGL KLAKADKNEI KKRVDHAADI
LQLGHLLERQ PKALSGGQRQ RVAIGRTLVS QPDVFLLDEP LSNLDAALRV QMRIEIAKLH
KKLGCTMIYV THDQVEAMTM AEKIVVLDGG YVSQVGAPLE LYHYPKNRFV AGFIGSPKMN
FVSVFIEEVE KSQVKVQFKN GASFWIPVDG SNVKRGERMS LGIRPEHLVP AENGDAVIDG
DILVVEKLGY ETQIYLTIED GDADMIYRVP DTALVKAGER FSVGIPAHRC HLFHNDGKAC
QRLYKEAGV