ID   MALK_ECOUT              Reviewed;         371 AA.
AC   Q1R3Q1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Maltose/maltodextrin import ATP-binding protein MalK {ECO:0000255|HAMAP-Rule:MF_01709};
DE            EC=7.5.2.1 {ECO:0000255|HAMAP-Rule:MF_01709};
GN   Name=malK {ECO:0000255|HAMAP-Rule:MF_01709}; OrderedLocusNames=UTI89_C4605;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC       maltose/maltodextrin import. Responsible for energy coupling to the
CC       transport system. {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:22132, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17306, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01709};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC       two transmembrane proteins (MalG and MalK) and a solute-binding protein
CC       (MalE). {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01709}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01709}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Maltooligosaccharide importer (TC 3.A.1.1.1) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE10013.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000243; ABE10013.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000179165.1; NC_007946.1.
DR   PDB; 2R6G; X-ray; 2.80 A; A/B=1-371.
DR   PDBsum; 2R6G; -.
DR   AlphaFoldDB; Q1R3Q1; -.
DR   SMR; Q1R3Q1; -.
DR   PRIDE; Q1R3Q1; -.
DR   EnsemblBacteria; ABE10013; ABE10013; UTI89_C4605.
DR   GeneID; 66672050; -.
DR   KEGG; eci:UTI89_C4605; -.
DR   HOGENOM; CLU_000604_1_1_6; -.
DR   OMA; SPKAFLM; -.
DR   EvolutionaryTrace; Q1R3Q1; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR   GO; GO:0015423; F:ABC-type maltose transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03301; ABC_MalK_N; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015855; ABC_transpr_MalK-like.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR040582; OB_MalK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF17912; OB_MalK; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51245; MALK; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Sugar transport; Translocase; Transport.
FT   CHAIN           1..371
FT                   /note="Maltose/maltodextrin import ATP-binding protein
FT                   MalK"
FT                   /id="PRO_0000273993"
FT   DOMAIN          4..234
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
SQ   SEQUENCE   371 AA;  40990 MW;  240D58F59450F30E CRC64;
     MASVQLQNVT KAWGEVVVSK DINLDIHEGE FVVFVGPSGC GKSTLLRMIA GLETITSGDL
     FIGEKRMNDT PPAERGVGMV FQSYALYPHL SVAENMSFGL KLAGAKKEVI NQRVNQVAEV
     LQLAHLLDRK PKALSGGQRQ RVAIGRTLVA EPSVFLLDEP LSNLDAALRV QMRIEISRLH
     KRLGRTMIYV THDQVEAMTL ADKIVVLDAG RVAQVGKPLE LYHYPADRFV AGFIGSPKMN
     FLPVKVTATA IDQVQVELPM PNRQQVWLPV ESRDVQVGAN MSLGIRPEHL LPSDIADVIL
     EGEVQVVEQL GNETQIHIQI PSIRQNLVYR QNDVVLVEEG ATFAIGLPPE RCHLFREDGT
     ACRRLHKEPG V