ID   MALK_VIBCH              Reviewed;         373 AA.
AC   Q9KL04; Q9L531;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Maltose/maltodextrin import ATP-binding protein MalK {ECO:0000255|HAMAP-Rule:MF_01709};
DE            EC=7.5.2.1 {ECO:0000255|HAMAP-Rule:MF_01709};
GN   Name=malK {ECO:0000255|HAMAP-Rule:MF_01709}; OrderedLocusNames=VC_A0946;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25870 / Classical Inaba 569B / Serotype O1;
RA   Dutta P.P., Roychoudhury S., Chaudhuri K.;
RT   "Probable MalK protein of Vibrio cholerae.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC       maltose/maltodextrin import. Responsible for energy coupling to the
CC       transport system. {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:22132, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17306, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01709};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC       two transmembrane proteins (MalG and MalK) and a solute-binding protein
CC       (MalE). {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01709}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01709}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Maltooligosaccharide importer (TC 3.A.1.1.1) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01709}.
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DR   EMBL; AF259974; AAF70304.1; -; Genomic_DNA.
DR   EMBL; AE003853; AAF96842.1; -; Genomic_DNA.
DR   PIR; A82398; A82398.
DR   RefSeq; NP_233330.1; NC_002506.1.
DR   RefSeq; WP_000179238.1; NZ_LT906615.1.
DR   AlphaFoldDB; Q9KL04; -.
DR   SMR; Q9KL04; -.
DR   STRING; 243277.VC_A0946; -.
DR   DNASU; 2612547; -.
DR   EnsemblBacteria; AAF96842; AAF96842; VC_A0946.
DR   KEGG; vch:VC_A0946; -.
DR   PATRIC; fig|243277.26.peg.3558; -.
DR   eggNOG; COG3842; Bacteria.
DR   HOGENOM; CLU_000604_1_1_6; -.
DR   OMA; SPKAFLM; -.
DR   BioCyc; VCHO:VCA0946-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IBA:GO_Central.
DR   GO; GO:1990060; C:maltose transport complex; IBA:GO_Central.
DR   GO; GO:0015423; F:ABC-type maltose transporter activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03301; ABC_MalK_N; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015855; ABC_transpr_MalK-like.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013611; Transp-assoc_OB_typ2.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF08402; TOBE_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51245; MALK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Sugar transport; Translocase;
KW   Transport.
FT   CHAIN           1..373
FT                   /note="Maltose/maltodextrin import ATP-binding protein
FT                   MalK"
FT                   /id="PRO_0000092484"
FT   DOMAIN          4..234
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
FT   VARIANT         365
FT                   /note="K -> Q (in strain: Classical 569B / ATCC 25870 /
FT                   Serotype O1)"
SQ   SEQUENCE   373 AA;  41405 MW;  A15E521894CABA55 CRC64;
     MASVTLKNVC KAYGDVLISK NVDLEIQEGE FVVFVGPSGC GKSTLLRCIA GLEDITSGDL
     YIGEQRMNDV EPSKRGVGMV FQSYALYPHL NLYDNMSFGL KLSKADKSEI KKRVDHAAEI
     LQLSHLLDRQ PKALSGGQRQ RVAIGRTLVS QPNVFLLDEP LSNLDAALRV QMRSEITKLQ
     RKLGCTMIYV THDQVEAMTM ADKIVVLDAG FVSQVGKPLE LYHYPQNRFV AGFIGSPKMN
     FMSVFIEGVE KDRVQVQLSN GTTFWIPVDG TTVTRGERMS LGIRPEHLVE AEHGDAKIEG
     KVMIVEKLGN ETQVYMNLKG SDSDVIYRQP DTLDVETGDT LTIGIPAHRC HLFHSDGRAC
     RRLHKEKGVD LPA