MALK_VIBVU
ID MALK_VIBVU Reviewed; 371 AA.
AC Q8D3V0;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Maltose/maltodextrin import ATP-binding protein MalK {ECO:0000255|HAMAP-Rule:MF_01709};
DE EC=7.5.2.1 {ECO:0000255|HAMAP-Rule:MF_01709};
GN Name=malK {ECO:0000255|HAMAP-Rule:MF_01709}; OrderedLocusNames=VV2_1584;
OS Vibrio vulnificus (strain CMCP6).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=216895;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMCP6;
RA Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC maltose/maltodextrin import. Responsible for energy coupling to the
CC transport system. {ECO:0000255|HAMAP-Rule:MF_01709}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:22132, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17306, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.1;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01709};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC two transmembrane proteins (MalG and MalK) and a solute-binding protein
CC (MalE). {ECO:0000255|HAMAP-Rule:MF_01709}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01709}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01709}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC Maltooligosaccharide importer (TC 3.A.1.1.1) family.
CC {ECO:0000255|HAMAP-Rule:MF_01709}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016796; AAO08446.1; -; Genomic_DNA.
DR RefSeq; WP_011082430.1; NC_004460.2.
DR AlphaFoldDB; Q8D3V0; -.
DR SMR; Q8D3V0; -.
DR EnsemblBacteria; AAO08446; AAO08446; VV2_1584.
DR GeneID; 66966938; -.
DR KEGG; vvu:VV2_1584; -.
DR HOGENOM; CLU_000604_1_1_6; -.
DR OMA; SPKAFLM; -.
DR Proteomes; UP000002275; Chromosome 2.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0015423; F:ABC-type maltose transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03301; ABC_MalK_N; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015855; ABC_transpr_MalK-like.
DR InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013611; Transp-assoc_OB_typ2.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF08402; TOBE_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF50331; SSF50331; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51245; MALK; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Sugar transport; Translocase; Transport.
FT CHAIN 1..371
FT /note="Maltose/maltodextrin import ATP-binding protein
FT MalK"
FT /id="PRO_0000092486"
FT DOMAIN 4..234
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
SQ SEQUENCE 371 AA; 41042 MW; C01927AD1C1D6D0A CRC64;
MASVTLKNVC KAYGDVLISK NVDLEINEGE FVVFVGPSGC GKSTLLRCIA GLEDITSGDL
YIGEERMNDV EPSKRGVGMV FQSYALYPHL NLYDNMSFGL KLAKADKKEI DKRVEQAAEI
LQLGHLLERL PKALSGGQRQ RVAIGRTLVS QPKVFLLDEP LSNLDAALRV QMRAQITKLQ
RQLGCTMIYV THDQVEAMTM ADKIVVLDGG FVSQVGKPLE LYHYPENRFV AGFIGSPKMN
FMSVQIVDVE SERVQVKLSN GVTFWVPVDG TTVNKGDRMS LGVRPEHLVS SAQGDAVIDG
EVMIVEKLGN ETQVYLNLES ADADVIYRQP DTLDVDSGDR LEIGIPAHRC HLFHSDGRAC
KRLFNEKGVE R