ID   MALK_YERPA              Reviewed;         369 AA.
AC   Q1CC21;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Maltose/maltodextrin import ATP-binding protein MalK {ECO:0000255|HAMAP-Rule:MF_01709};
DE            EC=7.5.2.1 {ECO:0000255|HAMAP-Rule:MF_01709};
GN   Name=malK {ECO:0000255|HAMAP-Rule:MF_01709}; OrderedLocusNames=YPA_0032;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- FUNCTION: Part of the ABC transporter complex MalEFGK involved in
CC       maltose/maltodextrin import. Responsible for energy coupling to the
CC       transport system. {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:22132, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17306, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01709};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MalK),
CC       two transmembrane proteins (MalG and MalK) and a solute-binding protein
CC       (MalE). {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01709}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01709}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Maltooligosaccharide importer (TC 3.A.1.1.1) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01709}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000308; ABG12001.1; -; Genomic_DNA.
DR   RefSeq; WP_002212091.1; NZ_CP009906.1.
DR   AlphaFoldDB; Q1CC21; -.
DR   SMR; Q1CC21; -.
DR   EnsemblBacteria; ABG12001; ABG12001; YPA_0032.
DR   GeneID; 66843940; -.
DR   KEGG; ypa:YPA_0032; -.
DR   OMA; SPKAFLM; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR   GO; GO:0015423; F:ABC-type maltose transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03301; ABC_MalK_N; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015855; ABC_transpr_MalK-like.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR040582; OB_MalK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF17912; OB_MalK; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51245; MALK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Sugar transport; Translocase; Transport.
FT   CHAIN           1..369
FT                   /note="Maltose/maltodextrin import ATP-binding protein
FT                   MalK"
FT                   /id="PRO_0000274002"
FT   DOMAIN          4..234
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01709"
SQ   SEQUENCE   369 AA;  40839 MW;  CF4F0D7029E193D1 CRC64;
     MANVTLSSVY KAFGEAVISR DINLEIDDGE FVVFVGPSGC GKSTLLRMIA GLEDITSGEL
     LIGGKRMNEV PPSERGIGMV FQSYALYPHL SVAENMSFGL KLAGVKKAEI YQRVNQVAEV
     LQLAHLLDRR PKALSGGQRQ RVAIGRTLVS EPDVFLLDEP LSNLDAALRV QMRIEISRLH
     KRLERTMIYV THDQVEAMTL ADKIVVLDAG NIAQVGKPLE LYHYPANRFV AGFIGSPKMN
     FLPVKVTAAE PRQVQIELPN HQRVWLPVEG DQVQVGANMS LGIRPEHLLP SSASEVTLEG
     EIQVVEQLGN ETQIHIQIPA IRQNLVYRQN DVVLVEEGAT FSIGLPPHRC HLFREDGTAC
     KRLYQELGV