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MALL_HUMAN
ID   MALL_HUMAN              Reviewed;         153 AA.
AC   Q13021; B3KWR6; Q9BTU0;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=MAL-like protein;
DE   AltName: Full=Protein BENE;
GN   Name=MALL; Synonyms=BENE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Synovium;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-153.
RX   PubMed=7622049; DOI=10.1016/0378-1119(95)00161-x;
RA   Lautner-Rieske A., Thiebe R., Zachau H.G.;
RT   "Searching for non-V kappa transcripts from the human immunoglobulin kappa
RT   locus.";
RL   Gene 159:199-202(1995).
CC   -!- INTERACTION:
CC       Q13021; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-750078, EBI-19125216;
CC       Q13021; Q13520: AQP6; NbExp=3; IntAct=EBI-750078, EBI-13059134;
CC       Q13021; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-750078, EBI-11343438;
CC       Q13021; P18859: ATP5PF; NbExp=3; IntAct=EBI-750078, EBI-2606700;
CC       Q13021; Q8NFU1: BEST2; NbExp=3; IntAct=EBI-750078, EBI-19947314;
CC       Q13021; Q12983: BNIP3; NbExp=3; IntAct=EBI-750078, EBI-749464;
CC       Q13021; O60238: BNIP3L; NbExp=3; IntAct=EBI-750078, EBI-849893;
CC       Q13021; O95415: BRI3; NbExp=3; IntAct=EBI-750078, EBI-2874789;
CC       Q13021; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-750078, EBI-11532900;
CC       Q13021; P11912: CD79A; NbExp=3; IntAct=EBI-750078, EBI-7797864;
CC       Q13021; O95471: CLDN7; NbExp=3; IntAct=EBI-750078, EBI-740744;
CC       Q13021; O95484: CLDN9; NbExp=3; IntAct=EBI-750078, EBI-18341636;
CC       Q13021; Q8IUN9: CLEC10A; NbExp=3; IntAct=EBI-750078, EBI-2873246;
CC       Q13021; Q2HXU8-2: CLEC12B; NbExp=3; IntAct=EBI-750078, EBI-12811991;
CC       Q13021; Q86T13: CLEC14A; NbExp=3; IntAct=EBI-750078, EBI-17710733;
CC       Q13021; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-750078, EBI-18013275;
CC       Q13021; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-750078, EBI-6942903;
CC       Q13021; Q13324-2: CRHR2; NbExp=3; IntAct=EBI-750078, EBI-23865243;
CC       Q13021; P16410: CTLA4; NbExp=3; IntAct=EBI-750078, EBI-1030991;
CC       Q13021; Q9Y4D2: DAGLA; NbExp=3; IntAct=EBI-750078, EBI-12808806;
CC       Q13021; Q96PD2-2: DCBLD2; NbExp=3; IntAct=EBI-750078, EBI-12135455;
CC       Q13021; Q9NXB9: ELOVL2; NbExp=3; IntAct=EBI-750078, EBI-17206972;
CC       Q13021; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-750078, EBI-18535450;
CC       Q13021; P54849: EMP1; NbExp=3; IntAct=EBI-750078, EBI-4319440;
CC       Q13021; P22794: EVI2A; NbExp=3; IntAct=EBI-750078, EBI-2870359;
CC       Q13021; P12314: FCGR1A; NbExp=3; IntAct=EBI-750078, EBI-2869867;
CC       Q13021; O15552: FFAR2; NbExp=3; IntAct=EBI-750078, EBI-2833872;
CC       Q13021; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-750078, EBI-12142257;
CC       Q13021; Q9UJ14: GGT7; NbExp=6; IntAct=EBI-750078, EBI-1058791;
CC       Q13021; P48165: GJA8; NbExp=3; IntAct=EBI-750078, EBI-17458373;
CC       Q13021; Q99795: GPA33; NbExp=3; IntAct=EBI-750078, EBI-4289554;
CC       Q13021; P16871: IL7R; NbExp=3; IntAct=EBI-750078, EBI-80490;
CC       Q13021; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-750078, EBI-749265;
CC       Q13021; P26715: KLRC1; NbExp=3; IntAct=EBI-750078, EBI-9018187;
CC       Q13021; Q5T700: LDLRAD1; NbExp=7; IntAct=EBI-750078, EBI-10173166;
CC       Q13021; O95214: LEPROTL1; NbExp=3; IntAct=EBI-750078, EBI-750776;
CC       Q13021; Q9NQG1: MANBAL; NbExp=3; IntAct=EBI-750078, EBI-3867271;
CC       Q13021; Q8IX19: MCEMP1; NbExp=3; IntAct=EBI-750078, EBI-2816356;
CC       Q13021; Q9NXJ0: MS4A12; NbExp=6; IntAct=EBI-750078, EBI-10227644;
CC       Q13021; P21757: MSR1; NbExp=6; IntAct=EBI-750078, EBI-1776976;
CC       Q13021; P15941-11: MUC1; NbExp=3; IntAct=EBI-750078, EBI-17263240;
CC       Q13021; P35372-10: OPRM1; NbExp=3; IntAct=EBI-750078, EBI-12807478;
CC       Q13021; O15173: PGRMC2; NbExp=3; IntAct=EBI-750078, EBI-1050125;
CC       Q13021; Q9NZK7: PLA2G2E; NbExp=3; IntAct=EBI-750078, EBI-13380620;
CC       Q13021; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-750078, EBI-10192441;
CC       Q13021; Q96GF1: RNF185; NbExp=3; IntAct=EBI-750078, EBI-2340249;
CC       Q13021; O43699-3: SIGLEC6; NbExp=3; IntAct=EBI-750078, EBI-12161783;
CC       Q13021; Q9Y3P8: SIT1; NbExp=3; IntAct=EBI-750078, EBI-6977215;
CC       Q13021; Q14973: SLC10A1; NbExp=3; IntAct=EBI-750078, EBI-3923031;
CC       Q13021; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-750078, EBI-18159983;
CC       Q13021; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-750078, EBI-17595455;
CC       Q13021; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-750078, EBI-17295964;
CC       Q13021; Q9H169-2: STMN4; NbExp=3; IntAct=EBI-750078, EBI-20117546;
CC       Q13021; Q16623: STX1A; NbExp=3; IntAct=EBI-750078, EBI-712466;
CC       Q13021; Q8N205: SYNE4; NbExp=3; IntAct=EBI-750078, EBI-7131783;
CC       Q13021; Q8N205-2: SYNE4; NbExp=3; IntAct=EBI-750078, EBI-12099160;
CC       Q13021; Q8N9I0: SYT2; NbExp=3; IntAct=EBI-750078, EBI-8032987;
CC       Q13021; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-750078, EBI-7238458;
CC       Q13021; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-750078, EBI-10255122;
CC       Q13021; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-750078, EBI-10314986;
CC       Q13021; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-750078, EBI-11742770;
CC       Q13021; Q9Y320: TMX2; NbExp=3; IntAct=EBI-750078, EBI-6447886;
CC       Q13021; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-750078, EBI-10180829;
CC       Q13021; P21754-3: ZP3; NbExp=3; IntAct=EBI-750078, EBI-17458299;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR   EMBL; AK125647; BAG54228.1; -; mRNA.
DR   EMBL; CH878608; EAW50639.1; -; Genomic_DNA.
DR   EMBL; BC003179; AAH03179.1; -; mRNA.
DR   EMBL; U17077; AAA76738.1; -; mRNA.
DR   CCDS; CCDS2085.1; -.
DR   PIR; I38891; I38891.
DR   RefSeq; NP_005425.1; NM_005434.4.
DR   AlphaFoldDB; Q13021; -.
DR   BioGRID; 113606; 150.
DR   IntAct; Q13021; 68.
DR   STRING; 9606.ENSP00000272462; -.
DR   iPTMnet; Q13021; -.
DR   PhosphoSitePlus; Q13021; -.
DR   BioMuta; MALL; -.
DR   DMDM; 21264403; -.
DR   MassIVE; Q13021; -.
DR   PaxDb; Q13021; -.
DR   PeptideAtlas; Q13021; -.
DR   PRIDE; Q13021; -.
DR   ProteomicsDB; 59108; -.
DR   Antibodypedia; 54954; 5 antibodies from 5 providers.
DR   DNASU; 7851; -.
DR   Ensembl; ENST00000272462.3; ENSP00000272462.2; ENSG00000144063.4.
DR   GeneID; 7851; -.
DR   KEGG; hsa:7851; -.
DR   MANE-Select; ENST00000272462.3; ENSP00000272462.2; NM_005434.5; NP_005425.1.
DR   UCSC; uc002tfk.3; human.
DR   CTD; 7851; -.
DR   DisGeNET; 7851; -.
DR   GeneCards; MALL; -.
DR   HGNC; HGNC:6818; MALL.
DR   HPA; ENSG00000144063; Tissue enhanced (esophagus, intestine).
DR   MIM; 602022; gene.
DR   neXtProt; NX_Q13021; -.
DR   OpenTargets; ENSG00000144063; -.
DR   PharmGKB; PA30567; -.
DR   VEuPathDB; HostDB:ENSG00000144063; -.
DR   eggNOG; ENOG502S02H; Eukaryota.
DR   GeneTree; ENSGT00940000161444; -.
DR   HOGENOM; CLU_112950_1_0_1; -.
DR   InParanoid; Q13021; -.
DR   OMA; YFINTAA; -.
DR   OrthoDB; 1438235at2759; -.
DR   PhylomeDB; Q13021; -.
DR   TreeFam; TF316174; -.
DR   PathwayCommons; Q13021; -.
DR   SignaLink; Q13021; -.
DR   BioGRID-ORCS; 7851; 33 hits in 1057 CRISPR screens.
DR   ChiTaRS; MALL; human.
DR   GeneWiki; MALL; -.
DR   GenomeRNAi; 7851; -.
DR   Pharos; Q13021; Tdark.
DR   PRO; PR:Q13021; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q13021; protein.
DR   Bgee; ENSG00000144063; Expressed in lower esophagus mucosa and 99 other tissues.
DR   ExpressionAtlas; Q13021; baseline and differential.
DR   Genevisible; Q13021; HS.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IDA:HGNC-UCL.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IDA:HGNC-UCL.
DR   GO; GO:0000139; C:Golgi membrane; IDA:HGNC-UCL.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0045121; C:membrane raft; IDA:HGNC-UCL.
DR   GO; GO:0005886; C:plasma membrane; IDA:HGNC-UCL.
DR   GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR   GO; GO:0042632; P:cholesterol homeostasis; NAS:HGNC-UCL.
DR   GO; GO:0042552; P:myelination; IBA:GO_Central.
DR   InterPro; IPR013295; MAL.
DR   InterPro; IPR008253; Marvel.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR01884; MALPROTEIN.
DR   PROSITE; PS51225; MARVEL; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="MAL-like protein"
FT                   /id="PRO_0000156811"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          22..153
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ   SEQUENCE   153 AA;  17350 MW;  83B30F1D950C5745 CRC64;
     MASPDPPATS YAPSDVPSGV ALFLTIPFAF FLPELIFGFL VWTMVAATHI VYPLLQGWVM
     YVSLTSFLIS LMFLLSYLFG FYKRFESWRV LDSLYHGTTG ILYMSAAVLQ VHATIVSEKL
     LDPRIYYINS AASFFAFIAT LLYILHAFSI YYH
 
 
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