MALL_MOUSE
ID MALL_MOUSE Reviewed; 154 AA.
AC Q91X49; Q3TQ65;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=MAL-like protein;
DE AltName: Full=Protein BENE;
GN Name=Mall; Synonyms=Bene;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR EMBL; AK078971; BAC37487.1; -; mRNA.
DR EMBL; AK163867; BAE37520.1; -; mRNA.
DR EMBL; BC012256; AAH12256.1; -; mRNA.
DR CCDS; CCDS16708.1; -.
DR RefSeq; NP_663507.1; NM_145532.3.
DR AlphaFoldDB; Q91X49; -.
DR STRING; 10090.ENSMUSP00000028856; -.
DR PhosphoSitePlus; Q91X49; -.
DR PaxDb; Q91X49; -.
DR PRIDE; Q91X49; -.
DR Antibodypedia; 54954; 5 antibodies from 5 providers.
DR DNASU; 228576; -.
DR Ensembl; ENSMUST00000028856; ENSMUSP00000028856; ENSMUSG00000027377.
DR GeneID; 228576; -.
DR KEGG; mmu:228576; -.
DR UCSC; uc008mfx.1; mouse.
DR CTD; 7851; -.
DR MGI; MGI:2385152; Mall.
DR VEuPathDB; HostDB:ENSMUSG00000027377; -.
DR eggNOG; ENOG502S02H; Eukaryota.
DR GeneTree; ENSGT00940000161444; -.
DR HOGENOM; CLU_112950_1_0_1; -.
DR InParanoid; Q91X49; -.
DR OMA; YFINTAA; -.
DR OrthoDB; 1438235at2759; -.
DR PhylomeDB; Q91X49; -.
DR TreeFam; TF316174; -.
DR BioGRID-ORCS; 228576; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q91X49; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q91X49; protein.
DR Bgee; ENSMUSG00000027377; Expressed in esophagus and 94 other tissues.
DR Genevisible; Q91X49; MM.
DR GO; GO:0030136; C:clathrin-coated vesicle; ISS:HGNC-UCL.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:HGNC-UCL.
DR GO; GO:0000139; C:Golgi membrane; ISS:HGNC-UCL.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; ISS:HGNC-UCL.
DR GO; GO:0005886; C:plasma membrane; ISS:HGNC-UCL.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0042552; P:myelination; IBA:GO_Central.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..154
FT /note="MAL-like protein"
FT /id="PRO_0000156812"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 24..154
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 154 AA; 17470 MW; 2783379F6EFB1DE3 CRC64;
MASRDTPPAT SYAPPDVPSG VAALFLTIPF AFFLPELVFG FWVWTLVAAT HVAYPLLQGW
VLYVSLTSFL ISLMFLMSYL FGFYKRFESW RVLDSLYHGT TGILYMSASV LQAYATIISE
GHNLSHYYIN VAASFFAFLT TLLYILHAFS IYYH
