ID   MALP_UREPA              Reviewed;         834 AA.
AC   Q9PRA0;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Membrane-associated lipoprotein;
DE   Flags: Precursor;
GN   OrderedLocusNames=UU045;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1] {ECO:0000312|EMBL:AAF30450.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
RN   [2] {ECO:0000305, ECO:0000312|PDB:3K63}
RP   STRUCTURE BY NMR OF 128-239, AND X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF
RP   133-249.
RX   PubMed=21153711; DOI=10.1007/s10969-010-9099-2;
RG   Northeast structural genomics consortium (NESG);
RA   Mani R., Vorobiev S., Swapna G.V., Neely H., Janjua H., Ciccosanti C.,
RA   Xiao R., Acton T.B., Everett J.K., Hunt J., Montelione G.T.;
RT   "Solution NMR and X-ray crystal structures of membrane-associated
RT   Lipoprotein-17 domain reveal a novel fold.";
RL   J. Struct. Funct. Genomics 12:27-32(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF222894; AAF30450.1; -; Genomic_DNA.
DR   RefSeq; WP_006688743.1; NC_002162.1.
DR   PDB; 2KRT; NMR; -; A=128-239.
DR   PDB; 3JVC; X-ray; 2.69 A; A/B/C=133-249.
DR   PDB; 3K63; X-ray; 2.49 A; A=133-249.
DR   PDBsum; 2KRT; -.
DR   PDBsum; 3JVC; -.
DR   PDBsum; 3K63; -.
DR   AlphaFoldDB; Q9PRA0; -.
DR   BMRB; Q9PRA0; -.
DR   SMR; Q9PRA0; -.
DR   STRING; 273119.UU045; -.
DR   EnsemblBacteria; AAF30450; AAF30450; UU045.
DR   GeneID; 29672285; -.
DR   KEGG; uur:UU045; -.
DR   eggNOG; ENOG5033SXH; Bacteria.
DR   HOGENOM; CLU_015669_0_0_14; -.
DR   OMA; SMWINAD; -.
DR   EvolutionaryTrace; Q9PRA0; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007326; Lipoprotein-assoc_dom.
DR   InterPro; IPR022382; Mycoplasma_peptidase_DUF31.
DR   InterPro; IPR022381; Uncharacterised_MG067.
DR   Pfam; PF01732; DUF31; 1.
DR   Pfam; PF04200; Lipoprotein_17; 2.
DR   PRINTS; PR00840; Y06768FAMILY.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           26..834
FT                   /note="Membrane-associated lipoprotein"
FT                   /id="PRO_0000413662"
FT   DOMAIN          143..237
FT                   /note="Lipoprotein-associated type-17"
FT   LIPID           26
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           26
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   HELIX           135..138
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   HELIX           139..141
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   TURN            144..146
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   STRAND          147..152
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   HELIX           160..162
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   HELIX           165..171
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   HELIX           172..174
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   STRAND          176..180
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   TURN            184..186
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   STRAND          187..195
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   STRAND          197..199
FT                   /evidence="ECO:0007829|PDB:2KRT"
FT   HELIX           201..207
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   STRAND          210..218
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   TURN            219..221
FT                   /evidence="ECO:0007829|PDB:3K63"
FT   STRAND          224..231
FT                   /evidence="ECO:0007829|PDB:3K63"
SQ   SEQUENCE   834 AA;  95985 MW;  01B5A9B2AC6BFDCA CRC64;
     MKKNKLTTLA LILPITILTP IVIASCTNKT KVKKSSSLDK IASNLKLEYF NNKANTKASS
     VQKDEIKKPL NLPNDVVFSV KDVFVSHKDQ SVLIVKYTLK KGNEIQEYTY EIKGFKSVYE
     KDKIVNDLSQ ANEDFKKIVN NIRLKDTFDF KLAAFPNQNY DQLLPSQIYK NYYQGIEIQQ
     HKYQNELDIK IINFLYPDGD FGSANKNGTL KLSLMLTDKK NNQVYYKLLE VSGFKSNPYG
     VDENGTIPGI GTERLKPKNQ DDYFSKTQLQ RYEIDNEGYL QILKRQNNDK NWKELRPDLN
     ATVSDIKHFD EKAKNVGQDS YESAAYKGFT LPVYESDGKI SGLALAGKDT PKGPSWVDAI
     GRNQWQIGGL PRTLPNEKYR QEAMQTFSLG ILNNDSHKNN TYNKTAGTTW ILDYQKTSDN
     KYPTKWYFAT NLHVADAINE NTLSINLMRL MDSAQIKTTF RLSNLDENIY NFGFRSKEHG
     KNLLNHGLKK IFDGRDFLKT KPAEYLINSQ KEKYKDVGNF TDFAVFELDF EKLELVNVWK
     NFLGENNGLV TKYNNYNPQE LAKVITSNYA NNKNNQIKFL SKSYLSDYSK IDVPLKYRQE
     DAKTWFKKYD ELFALGWPNS TEDFFFKAYV DDDQLKYRTR DNFSLWTNSD YRFFNNLTQQ
     EGGQPAFPPE RTERGNYLSY AIGFRSFIQK PGIVDAFIAV PQIGNNLYTS SDNKKYINMG
     LEYLPKHFAP AGGASGTSVR NQKNELVAIY HAKYDSSKTG LAAAFRSEGY DYQGLYGNYN
     LPQYDLIYGG GKDQTEKKSY REAMKDIYQN NNIKTALFPD GFDKIPDEFK FNNN