ID   MALR_CLOBU              Reviewed;         335 AA.
AC   O05103;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=HTH-type transcriptional regulator MalR;
OS   Clostridium butyricum.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1492;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 19398 / DSM 10702 / JCM 1391 / NCIMB 7423;
RA   Goda S.K., Minton N.P.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Repressor of glucanotransferase gene expression.
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DR   EMBL; Y10554; CAA71586.1; -; Genomic_DNA.
DR   AlphaFoldDB; O05103; -.
DR   SMR; O05103; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..335
FT                   /note="HTH-type transcriptional regulator MalR"
FT                   /id="PRO_0000107968"
FT   DOMAIN          1..55
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        3..22
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   335 AA;  37462 MW;  B47F98937834E23D CRC64;
     MNIKDIARLS GVGVSTVSRV INNHPDVKQS TREKVLQIIK DSNYIPNNSA RILKQNNTKN
     IGVLVKGVFN PFFSEMTNII GNIIEENGYT MILQQNDFNL YQDVETMIGF VKEKRLQGVI
     CLGGNFTEIQ EDSFEDIKVP VVLTSVNTIS KKGKKYYSSV GIDNSKSAYK AVRYLIERVI
     KDCFGLGEVN DLGVSWWRLD GYKKALGENN IDIDDELIIS GEYNSGTAYE NVNKLLKKRK
     DITAIFALSD IMALGAIKAA IDNGLDVPRD ISIVGFDGMD ESKYYNPSIT TVKQPKKKMA
     ETSVELLFSL ITTDGENKHV ILDTELVERD SCFNI