ID   MALR_STAXY              Reviewed;         337 AA.
AC   Q56201;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=HTH-type transcriptional regulator MalR;
DE   AltName: Full=Maltose operon transcriptional repressor;
GN   Name=malR;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=7730272; DOI=10.1128/jb.177.9.2408-2415.1995;
RA   Egeter O., Brueckner R.;
RT   "Characterization of a genetic locus essential for maltose-maltotriose
RT   utilization in Staphylococcus xylosus.";
RL   J. Bacteriol. 177:2408-2415(1995).
CC   -!- FUNCTION: Transcriptional repressor of the malA gene for maltase.
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DR   EMBL; X78853; CAA55408.1; -; Genomic_DNA.
DR   PIR; S44187; S44187.
DR   RefSeq; WP_047172334.1; NZ_LN554884.1.
DR   AlphaFoldDB; Q56201; -.
DR   SMR; Q56201; -.
DR   STRING; 1288.SXYLSMQ121_1285; -.
DR   KEGG; sxo:SXYL_01350; -.
DR   eggNOG; COG1609; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..337
FT                   /note="HTH-type transcriptional regulator MalR"
FT                   /id="PRO_0000107969"
FT   DOMAIN          1..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   337 AA;  37691 MW;  C028E1FB91E695A8 CRC64;
     MVTIKDIAQA ANVSTSTVSR VISGNPRISM QTREKVKATM KSFNYQPNRA ARTLATKQSN
     TIGIIQKSAS IEDSQNPFVL DVLSGIFSKC KNHGYATIST TKGQSIEIEL EVQEMIHYHS
     VDGFIVLYSK KSDPIIDILK SHAMPYVIIG KPLTDDDIIH IDNDNVSASQ SLTRYLIDKG
     HNKFLFVAET GNYEVVKDRI AGHLNAIEQT DSVTDIVYFA KNRHYIRSFF QDLIEHRTLP
     TVVITSDTLL NHLILSVFYE LKLHIPTDIQ TATFNDSYLN AFASPPQTTV DIYPKLLGEG
     AAESAINIIQ GHNILNFYKL IPTTIIERES TTTIQEV