ID   MALR_STRCO              Reviewed;         344 AA.
AC   P72396;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 2.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=HTH-type transcriptional regulator MalR;
DE   AltName: Full=Maltose operon transcriptional repressor;
GN   Name=malR; OrderedLocusNames=SCO2232; ORFNames=SC10B7.27;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=9044287; DOI=10.1046/j.1365-2958.1997.d01-1878.x;
RA   van Wezel G.P., White J., Young P., Postma P.W., Bibb M.J.;
RT   "Substrate induction and glucose repression of maltose utilization by
RT   Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacl-
RT   galR family of regulatory genes.";
RL   Mol. Microbiol. 23:537-549(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Transcriptional repressor of the maltosaccharide utilization
CC       operon malEFG.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y07706; CAA68975.1; -; Genomic_DNA.
DR   EMBL; AL939111; CAB90880.1; -; Genomic_DNA.
DR   RefSeq; NP_626483.1; NC_003888.3.
DR   RefSeq; WP_003976582.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; P72396; -.
DR   SMR; P72396; -.
DR   STRING; 100226.SCO2232; -.
DR   GeneID; 1097665; -.
DR   KEGG; sco:SCO2232; -.
DR   PATRIC; fig|100226.15.peg.2269; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_4_11; -.
DR   InParanoid; P72396; -.
DR   OMA; HSEFVFM; -.
DR   PhylomeDB; P72396; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..344
FT                   /note="HTH-type transcriptional regulator MalR"
FT                   /id="PRO_0000107970"
FT   DOMAIN          1..54
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   344 AA;  36351 MW;  CAC084B6C5E32E26 CRC64;
     MTTRLADIAA QAGVSEATVS RVLNGKPGVA ATTRQSVLAA LDVLGYERPV RLRQRSEGLV
     GLITPELENP IFPALAQVIG QALTRQGYTP VLATQTPGGS TEDELTEMLV DRGVAGIIYV
     SGLHADTTAD MQRYERLRAQ GVPFVLVDGF SSQVQAPFIS PDDRAAMSLA VTHLVSLGHT
     RIGLALGPKR FVPVQRKIEG FVRTVQDQLG LSAETVEKEL VQHSLYTLEG GQAAASALIG
     RDCTAVVCAS DMMALGAIRA ARQLGLDVPK DVSVVGFDDS PLIAFTDPPL TTVRKPVPAM
     GQAAVRTLLE EIGGTPAPHS EFVFMPELVV RGSTASAPGE RGRP