ID   MALR_STRPN              Reviewed;         328 AA.
AC   P0A4T1; Q08511;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=HTH-type transcriptional regulator MalR;
DE   AltName: Full=Maltose operon transcriptional repressor;
GN   Name=malR; OrderedLocusNames=SP_2112;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Transcriptional repressor of the maltosaccharide utilization
CC       operons malxCD and malMP. {ECO:0000250}.
CC   -!- INTERACTION:
CC       P0A4T1; P95830: dnaJ; NbExp=2; IntAct=EBI-2207435, EBI-2207079;
CC       P0A4T1; Q97SE5: gatC; NbExp=2; IntAct=EBI-2207435, EBI-2207053;
CC       P0A4T1; Q97NV3: groES; NbExp=2; IntAct=EBI-2207435, EBI-2206949;
CC       P0A4T1; P05382: sulA; NbExp=2; IntAct=EBI-2207435, EBI-2206997;
CC       P0A4T1; Q97SR4: uppS; NbExp=2; IntAct=EBI-2207435, EBI-2206983;
CC       P0A4T1; Q97QP2: xerS; NbExp=2; IntAct=EBI-2207435, EBI-2207218;
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DR   EMBL; AE005672; AAK76171.1; -; Genomic_DNA.
DR   PIR; B49543; B49543.
DR   PIR; B95247; B95247.
DR   RefSeq; WP_001145439.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0A4T1; -.
DR   SMR; P0A4T1; -.
DR   IntAct; P0A4T1; 6.
DR   STRING; 170187.SP_2112; -.
DR   EnsemblBacteria; AAK76171; AAK76171; SP_2112.
DR   GeneID; 60233353; -.
DR   GeneID; 66807191; -.
DR   KEGG; spn:SP_2112; -.
DR   eggNOG; COG1609; Bacteria.
DR   OMA; ARWVGPP; -.
DR   BioCyc; SPNE170187:G1FZB-2200-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..328
FT                   /note="HTH-type transcriptional regulator MalR"
FT                   /id="PRO_0000107971"
FT   DOMAIN          2..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   REGION          173..218
FT                   /note="Inducer binding"
FT                   /evidence="ECO:0000255"
FT   REGION          282..291
FT                   /note="Dimerization"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  37044 MW;  0D8026C93ECB232D CRC64;
     MPVTIKDVAK AAGVSPSTVT RVIQNKSTIS DETKKRVRKA MKELNYHPNL NARSLVSSYT
     QVIGLVLPDD SDAFYQNPFF PSVLRGISQV ASENHYAIQI ATGKDEKERL NAISQMVYGK
     RVDGLIFLYA QEEDPLVKLV AEEQFPFLIL GKSLSPFIPL VDNDNVQAGF DATEYFIKKG
     CKRIAFIGGS KKLFVTKDRL TGYEQALKHY KLTTDNNRIY FADEFLEEKG YKFSKRLFKH
     DPQIDAIITT DSLLAEGVCN YIAKHQLDVP VLSFDSVNPK LNLAAYVDIN SLELGRVSLE
     TILQIINDNK NNKQICYRQL IAHKIIEK