ID   MALR_STRR6              Reviewed;         328 AA.
AC   P0A4T2; Q08511;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=HTH-type transcriptional regulator MalR;
DE   AltName: Full=Maltose operon transcriptional repressor;
GN   Name=malR; OrderedLocusNames=spr1922;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-3; 5-6 AND
RP   8-11.
RX   PubMed=8244973; DOI=10.1016/s0021-9258(19)74406-8;
RA   Puyet A., Ibanez A.M., Espinosa M.;
RT   "Characterization of the Streptococcus pneumoniae maltosaccharide regulator
RT   MalR, a member of the LacI-GalR family of repressors displaying distinctive
RT   genetic features.";
RL   J. Biol. Chem. 268:25402-25408(1993).
RN   [2]
RP   SEQUENCE REVISION TO 43-56.
RA   Puyet A.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Transcriptional repressor of the maltosaccharide utilization
CC       operons malxCD and malMP.
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DR   EMBL; L21856; AAB88011.1; -; Unassigned_DNA.
DR   EMBL; AE007317; AAL00724.1; -; Genomic_DNA.
DR   PIR; G98111; G98111.
DR   RefSeq; NP_359513.1; NC_003098.1.
DR   RefSeq; WP_001145439.1; NC_003098.1.
DR   AlphaFoldDB; P0A4T2; -.
DR   SMR; P0A4T2; -.
DR   STRING; 171101.spr1922; -.
DR   EnsemblBacteria; AAL00724; AAL00724; spr1922.
DR   GeneID; 60233353; -.
DR   GeneID; 66807191; -.
DR   KEGG; spr:spr1922; -.
DR   PATRIC; fig|171101.6.peg.2071; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_2_9; -.
DR   OMA; ARWVGPP; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; DNA-binding; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8244973"
FT   CHAIN           2..328
FT                   /note="HTH-type transcriptional regulator MalR"
FT                   /id="PRO_0000107972"
FT   DOMAIN          2..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   REGION          173..218
FT                   /note="Inducer binding"
FT                   /evidence="ECO:0000255"
FT   REGION          282..291
FT                   /note="Dimerization"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  37044 MW;  0D8026C93ECB232D CRC64;
     MPVTIKDVAK AAGVSPSTVT RVIQNKSTIS DETKKRVRKA MKELNYHPNL NARSLVSSYT
     QVIGLVLPDD SDAFYQNPFF PSVLRGISQV ASENHYAIQI ATGKDEKERL NAISQMVYGK
     RVDGLIFLYA QEEDPLVKLV AEEQFPFLIL GKSLSPFIPL VDNDNVQAGF DATEYFIKKG
     CKRIAFIGGS KKLFVTKDRL TGYEQALKHY KLTTDNNRIY FADEFLEEKG YKFSKRLFKH
     DPQIDAIITT DSLLAEGVCN YIAKHQLDVP VLSFDSVNPK LNLAAYVDIN SLELGRVSLE
     TILQIINDNK NNKQICYRQL IAHKIIEK